咪达那新合成工艺的改进

目的：对咪达那新的合成工艺进行改进。方法：以二苯乙腈为起始原料，经缩合1、缩合2及水解得到目标产物。结果：经三步合成了目标产物，总收率为68%，目标化合物结构经1HNMR和MS确证。结论：本合成方法原料易得，反应条件温和，适合工业化生产。

Improvement on the synthesis process of Imidafenacin

Objective: To improve the synthesis process of Imidafenacin. Methods: Starting with diphenylacetonitrile, the target compound was prepared through a three-step procedure including condensation 1, condensation 2 and hydrolysis reaction. Results:The target compound was obtained in an overall yield of 68%. The structure of target compound was confirmed by 1HNMR and MS. Conclusion:The optimized process with easily purchased materials, facile reaction conditions and convenient operation procedures promises a scale-up manufacture.