A mild and metal-free synthesis of 2- and 1-alkyl/aryl/dialkyl-aminoquinolines and isoquinolines |
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| Authors: | Yerramsetti Nanaji Seema Kirar Sandip V. Pawar Ashok Kumar Yadav |
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| Affiliation: | Texas Tech University Health Sciences Center, Ophthalmology Department Lubbock General, 3601 4th Street, Lubbock TX 79430 USA ; Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER), Sector-67, S. A. S. Nagar-160062, Punjab India ; University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014 India, |
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| Abstract: | A simple synthetic strategy has been developed for the synthesis of 2- and 1-alkyl/aryl/dialkylaminoquinolines and isoquinolines from the easily available quinoline and isoquinoline-N-oxides, different amines, triflic anhydride as activating agent and acetonitrile as solvent in a one-pot reaction under metal-free conditions at 0 °C to room temperature.A synthetic strategy has been developed for synthesis of 2 and 1-aminoquinolines and isoquinolines from quinoline and isoquinoline-N-oxides, amines and triflic anhydride in acetonitrile at 0 °C to room temperature. |
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