Nickel catalyzed intramolecular oxidative coupling: synthesis of 3-aryl benzofurans |
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| Authors: | Sakshi Aggarwal Dasari Srinivas Chinnabattigalla Sreenivasulu Gedu Satyanarayana |
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| Affiliation: | Department of Chemistry, Indian Institute of Technology, Kandi, Sangareddy, Hyderabad 502 285 Telangana India, Fax: +91 40 2301 6003/32, +91 40 2301 6033 |
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| Abstract: | Recent research has been focused on the transition metal-catalyzed reactions. Herein we have developed nickel-catalyzed synthesis of 3-aryl benzofurans from ortho-alkenyl phenols via intramolecular dehydrogenative coupling. Notably, simple O2 gas served as an oxidant, without using any sacrificial hydrogen acceptor. The strategy enabled the synthesis of 3-aryl benzofurans in good to excellent yields.We have developed nickel-catalyzed synthesis of 3-aryl benzofurans from ortho-alkenyl phenols via intramolecular dehydrogenative coupling. O2 gas served as an oxidant and 3-aryl benzofurans were synthesized in good to very good yields. |
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