Chlorotrifluoroethylidenes: an efficient and convenient approach to their synthesis |
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| Authors: | Abhay Atmaram Upare Pradip K. Gadekar Kiran Jadhav H. Sivaramakrishnan Selvaraj Mohana Roopan |
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| Affiliation: | Chemistry of Heterocycles and Natural Product Research Lab, Department of Chemistry, School of Advanced Science, Vellore Institute of Technology, Vellore – 632014 Tamil Nadu India, +91-0416-220-2313 ; Department of Process Development, Piramal Enterprises Ltd., Lighthall A Wing, Hiranandani Business Park, Sakivihar Road, Chandivali, Andheri (East), Mumbai 400072 India |
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| Abstract: | A convenient one step synthesis of chlorotrifluoroalkyl olefins starting from aldehydes was developed. The stable reagent 2-((1-chloro-2,2,2-trifluoroethyl)sulfonyl)benzothiazole was prepared from readily available benzothiazole-2-thiol and halothane. This method comprises using stable 2-((1-chloro-2,2,2-trifluoroethyl)sulfonyl)benzothiazole according to the Julia procedure and presents new opportunities for the synthesis of trifluoroalkylidene derivatives.A convenient one step synthesis of chlorotrifluoroalkyl olefins starting from aldehydes was developed. |
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