New synthesis of 2-aroylbenzothiazoles via metal-free domino transformations of anilines,acetophenones, and elemental sulfur |
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Authors: | Tien V. Huynh Khang V. Doan Ngoc T. K. Luong Duyen T. P. Nguyen Son H. Doan Tung T. Nguyen Nam T. S. Phan |
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Affiliation: | Faculty of Chemical Engineering, Ho Chi Minh City University of Technology (HCMUT), 268 Ly Thuong Kiet, District 10, Ho Chi Minh City Vietnam, Fax: +84 8 38637504, +84 8 38647256 ext. 5681 ; Vietnam National University Ho Chi Minh City, Linh Trung Ward, Thu Duc District, Ho Chi Minh City Vietnam ; Faculty of Chemical Technology, Ho Chi Minh City University of Food Industry (HUFI), 140 Le Trong Tan, Tan Phu District, Ho Chi Minh City Vietnam |
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Abstract: | A new synthesis of 2-aroylbenzothiazoles via iodine-promoted domino transformations of anilines, acetophenones, and elemental sulfur was demonstrated. The highlights of this tandem synthesis are (1) easily available anilines and acetophenones as feedstock; (2) transition metal-free conditions; (3) inexpensive, nontoxic, easy handling, and abundant elemental sulfur as a building block. This synthetic strategy would complement the existing methods in the synthesis of this important heterocyclic scaffold. To our best knowledge, the formation of 2-aroylbenzothiazoles from simple anilines, acetophenones, and elemental sulfur was not previously reported in the literature.A new synthesis of 2-aroylbenzothiazoles via iodine-promoted domino transformations of anilines, acetophenones, and elemental sulfur was demonstrated. |
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