Plasmacytoid dendritic cell precursors/type I interferon-producing cells sense viral infection by Toll-like receptor (TLR) 7 and TLR9 |
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Authors: | Ito Tomoki Wang Yui-Hsi Liu Yong-Jun |
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Institution: | (1) Department of Immunology and CCIR, The University of Texas, M. D. Anderson Cancer Center, Houston, TX 77030, USA |
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Abstract: | Plasmacytoid dendritic cell (pDC) precursors, also called type I IFN ( / / )-producing cells (IPCs), are the key effectors in the innate immune system because of their extraordinary capacity to produce type I IFNs against microbial infection, particularly viral infection. In contrast to myeloid DCs, human pDC/IPCs selectively express Toll-like receptor (TLR) 7 and TLR9 within the endosomal compartment. These receptors are specifically designed to recognize the nucleoside-based products derived from RNA viruses and DNA viruses. Therefore, this expression profile potentially enables pDC/IPCs to sense a variety of viruses. Stimulation of TLR7 or TLR9 leads to type I IFN responses through the MyD88 pathway. Thus, pDC/IPCs may play a central role in host defense against viral infection through the TLR7 and TLR9 system. |
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Keywords: | Innate immunity Single-stranded RNA CpG DNA MyD88 Anti-viral immunity |
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