血管内皮细胞生长因子在口底癌组织中的表达及作用的临床研究

目的：研究血管内皮细胞生长因子（VEGF）在老年口底癌组织中的地位及作用，探讨老年口底癌的发病机制、临床分期和病理分级及VEGF网络相关情况。方法：采用免疫组织化学S－P法检测40例口底癌组织、39例癌旁组织、10例正常口底粘膜组织并观察VEGF表达水平的动态变化。结果：VEGF表达水平明显高于健康对照组（均为P＜0．01）。随着病理分级和临床贫苦的增高，VEGF的阳性表达率和表达强度增增高呈正相关。结论：VEGF是口底癌中机体病理生理改变的重要血管生成因子，其过度表达在口底癌发生发展、浸润转移中起重要作用。

Clinical study of vascular endothelial growth fac tor expression(VEGF) in carcinoma of the floor of mouth

Objective To investigate the relationship between the expression level of VEGF(Vascular endothelial growth factor) in carcinoma of the floor of mouth and its clinical stages and clinicopathologic grade.Methods VEGF expression in 42 carcinoma of the floor of mouth tissues,30 paratorgue cancer tissues and 10 normal mucosa was examined by s p immunohistochemical method.Results Comparing with paratorgue cancer and normal tissues,VEGF was showed high expression( P <0 01).A significant correlation was found between the enhancement of positive expression rate and expression intensity of VEGF and the clinical stage or clinopathological division.Conclusions VEGF is a important vascular growth factor.Its over expression may be involved in the oncopathogenesis development and metastasis in carcinoma of the floor of mouth.