| FAK和MMP-9蛋白在结直肠癌组织中的表达及相关性研究 |
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| 引用本文： | 梁水权,吕益中,王羲中,王育烽.FAK和MMP-9蛋白在结直肠癌组织中的表达及相关性研究[J].结直肠肛门外科,2008,14(3). |
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| 作者姓名： | 梁水权 吕益中 王羲中 王育烽 |
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| 作者单位： | 广东省佛山市禅城区中心医院普外科,佛山,528000 |
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| 摘 要： | 目的 探讨斑激酶(focal adhesion kinase , FAK)和基质金属蛋白酶-9(matrix metalloproteinase,MMP-9)在结直肠癌中的表达.方法 采用免疫组化法检测了67例结直肠癌和癌旁组织以及51例正常结直肠黏膜组织中FAK和MMP-9的表达,并比较了不同临床病理参数下FAK和MMP-9的表达情况.结果 结直肠癌组织FAK阳性表达(77.6%,52/67)高于癌旁组织(50.8%,34/67)和正常结直肠黏膜组织(37.3%,19/51),结直肠癌组织中MMP-9染色阳性率(73.1%,49/67)高于癌旁组织(49.3%,33/67)和正常结直肠黏膜组织(31.4%,16/51),不同肿瘤分化、局部分期以及有无淋巴结转移者FAK和MMP-9表达水平存在差异(P<0. 05).结论 FAK和MMP-9在结直肠癌组织高表达,且FAK和MMP-9表达呈正相关,可能成为判断结直肠癌预后的指标之一.
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| 关 键 词： | 结直肠肿瘤 FAK MMP-9 免疫组织化学 蛋白 结直肠癌组织 表达水平 相关性研究 colorectal carcinoma matrix focal adhesion kinase expression correlation 指标 癌预后 判断 差异 存在 转移者 淋巴结 局部 肿瘤分化 阳性率 染色 |
Study of the correlation and expression of focal adhesion kinase and matrix metalloproteinase-9 in colorectal carcinoma |
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| Liang Shuiquan,Lu Yizhong,Wang Xizhong,et al..Study of the correlation and expression of focal adhesion kinase and matrix metalloproteinase-9 in colorectal carcinoma[J].Journal of Colorectal & Anal Surgery,2008,14(3). |
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| Authors: | Liang Shuiquan Lu Yizhong Wang Xizhong |
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| Institution: | Liang Shuiquan,Lu Yizhong,Wang Xizhong,et al. Central Hospital of Chancheng District,Foshan 528000,China |
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| Abstract: | Objective To investigate the correlation and expression of focal adhesion kinase (FAK) and matrix metalloproteinase-9(MMP-9) in colorectal carcinoma. Methods Expression of FAK and MMP-9 were detected immunohistochemically in 67 cases of colorectal carcinoma and 51 cases of normal colorectal mucosa. Results The expression of FAK was higher in colorectal carcinoma tissue (77.6%, 52/67) than that in peri-neoplasm tissue (50.8%, 34/67) and normal colorectal mucosa tissue (37.3%, 19/51). The expression of MMP-9 ... |
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| Keywords: | Colorectal carcinoma Focal adhesion kinase (FAK) Matrix Metalloproteinase-9 (MMP-9) Immunohistochemistry |
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