| GWe对兔疫应答过程中抗体产生及IL-1活性的影响 |
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| 引用本文： | 张萃,杨贵贞. GWe对兔疫应答过程中抗体产生及IL-1活性的影响[J]. 广东药学院学报, 1998, 0(1) |
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| 作者姓名： | 张萃 杨贵贞 |
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| 作者单位： | 广东药学院微生物与免疫学教研室!广州，510224(张萃)，白求恩医科大学免疫学教研室!长春，130021(杨贵贞) |
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| 摘 要： | 研究了GWe对HRBC免疫后的功能调节作用。在连续给中药GWe的基础上，采用HRBC免疫普通小鼠，选择免疫后不同时间：1，3，5，7，9，11天，用QHS及血凝效价测定方法检测小鼠血浆Ab的动态变化，Ab产生峰值在第5天，GWe组与对照组相比差异有显著性。同时又检测了免疫不同时间的ConA诱导脾细胞上清中IL-1活性的变化，结果表明IL-1活性变化峰值在第5天，GWe组与正常对照组比较差异有非常显著性（P＜0．01）。研究结果提示GWe不仅能提高Ab产生，亦可促进IL-1的产生。
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| 关 键 词： | GWe 免疫应答 抗体 IL-1 |
Effects of GWe on Levels of Antibody and IL-1 Activity in Immunization Response Process |
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| Zhang Cui, Yang Guizhen. Effects of GWe on Levels of Antibody and IL-1 Activity in Immunization Response Process[J]. Academic Journal of Guangdong College of Pharmacy, 1998, 0(1) |
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| Authors: | Zhang Cui Yang Guizhen |
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| Abstract: | GWe is a new hiological modifier extracted from traditional Chinese medicine. After the administration of GWe for 3 days, the antibody titer in the plasma of HRBC immunized mice was measured in day 1, 3,5,7, 9 and 11 by QHS and bled agglutination method. The activities of IL-1 like substance of splenocytes in mice were also detected. It was found that the levels of antibody and IL-1 activity were significantly higher in the GWe group than those in NS control(P<0.05). The antibody and IL-1 level reached the maximum on the fifth day. These results suggested that the GWe could enhance the immunity function and increase the lgM synthesis and IL-1 activity. |
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| Keywords: | GWe immunized response antibody IL-1 |
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