| 喉鳞状细胞癌中C-erbB-2和E-钙粘附素蛋白表达及其意义 |
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| 引用本文： | 谷化平,尚培中. 喉鳞状细胞癌中C-erbB-2和E-钙粘附素蛋白表达及其意义[J]. 西南国防医药, 2008, 18(2): 198-200 |
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| 作者姓名： | 谷化平 尚培中 |
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| 作者单位： | 解放军第251医院病理科,河北,张家口,075000 |
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| 摘 要： | 目的：探讨癌基因c—erbB-2蛋白和黏附分子E-钙黏蛋白（E—cad）表达与喉鳞状细胞癌（LSCC）的发生、发展和生物学意义。方法：应用免疫组织化学方法，检测45例LSCC组织和15例声带息肉（VCP）组织中c—erbB-2和E—cad蚤白表达水平。结果：在LSCC组织中c—erbB-2和E—cad表达阳性率分别为75．6%（34／45）和62．2％（28／45）。LSCC中，c—erbB-2表达阳性率高于VCP（0／15，0．0%,40，X^2=22．12，P＜0．01），而E—cad表达阳性率低于VCP（15／15，100％，X^2=4．73，P〈0．05）。c—erbB-2高表达和E—cad低表达与LSCC分级和淋巴结转移相关（P〈0．05）。LSCC中c—erbB-2表达与E—cad表达呈负相关（r=-0．30）。结论：c—erbB-2和E—cad表达水平可作为判断LSCC分级和淋巴结转移和预后的重要参考指标。
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| 关 键 词： | 喉鳞状细胞癌 基因表达调控 肿瘤转移 免疫组织化学 |
| 文章编号： | 1004-0188(2008)02-0198-03 |
| 修稿时间： | 2007-08-27 |
Expression and biological significance of C-erbB-2 and E-cadherin in laryngeal squamous cell carcinomas |
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| GU Hua-ping,SHANG Pei-zhong. Expression and biological significance of C-erbB-2 and E-cadherin in laryngeal squamous cell carcinomas[J]. Medical Journal of National Defending forces in Southwest China, 2008, 18(2): 198-200 |
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| Authors: | GU Hua-ping SHANG Pei-zhong |
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| Affiliation: | GU Hua-ping,SHANG Pei-zhong Department of Pathology,Hospital 251 of PLA,Zhangjiakou,Hebei,075000,China. |
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| Abstract: | Objective:To study the biological significance of C-erbB-2 protein and E-cadherin protein expression in laryngeal squamous cell carcinomas(LSCC).Methods:The levels of expression of C-erbB-2 protein and E-cadherin protein in 45 cases of LSCC and 15 cases of vocal cord polyp (VCP) were examined with immunohistochemical method.Results:In LSCC group, the positive rates of C-erbB-2 protein and E-cad protein was 75.6%(34/45) and 62.2%(28/45), respectively. Compared with VCP group, the positive rate of C-erbB-2 wa... |
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| Keywords: | laryngeal squamous cell carcinoma gene expression neoplasm metastasis vocal cord polyp |
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