Older adults exhibit more intracortical inhibition and less intracortical facilitation than young adults |
| |
Authors: | Marisa McGinley Richard L. Hoffman David W. Russ James S. Thomas Brian C. Clark |
| |
Affiliation: | 1. Institute for Neuromusculoskeletal Research, Ohio University, United States;2. Department of Biomedical Sciences, Ohio University, United States;3. School of Physical Therapy, Ohio University, United States |
| |
Abstract: | BackgroundAging results in decreased neuromuscular function, which is likely associated with neurologic alterations. At present little is known regarding age-related changes in intracortical properties.MethodsIn this study we used transcranial magnetic stimulation (TMS) to measure intracortical facilitation (ICF), short- and long-interval intracortical inhibition (SICI and LICI), motor evoked potential amplitude, and silent period duration in young and older adults (21.4 ± 0.8 years and 70.9 ± 1.8 years). These variables were assessed from the flexor carpi radialis muscle of the non-dominant arm under resting conditions, and during a submaximal contraction (intensity 15% maximum strength).ResultsOlder adults exhibited increased SICI and LICI in comparison to young adults (SICI: 29.0 ± 9.2% vs. 46.2 ± 4.8% of unconditioned pulse; LICI: 6.5 ± 1.7% vs. 15.8 ± 3.3% of unconditioned pulse; P = 0.04), and less ICF under resting conditions (74.6 ± 8.7% vs. 104.9 ± 6.9% of unconditioned pulse; P = 0.02). These age-related differences disappeared during contraction, although the older adults did exhibit a longer silent period during contraction (112.5 ± 6.5 vs. 84.0 ± 3.9 ms; P < 0.01).ConclusionsCollectively, these findings suggest increased GABA mediated intracortical inhibition with age. |
| |
Keywords: | Transcranial magnetic stimulation Muscle Motor evoked potential Aging Sarcopenia Dynapenia Electromyography |
本文献已被 ScienceDirect 等数据库收录! |
|