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NADPH oxidase-derived superoxide impairs calcium transients and contraction in aged murine ventricular myocytes |
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| Authors: | Uwe Rueckschloss,Marten VillmowUdo Klö ckner |
| Affiliation: | Julius Bernstein Institute of Physiology, Martin Luther University Halle, Germany |
| Abstract: | Since aging increases oxidative stress, we analyzed the contribution of reactive oxygen species (ROS) to the contractile dysfunction of aged ventricular myocytes and investigated whether short-term interference with ROS formation could normalize contractile performance. |
| Keywords: | Aging Cardiac myocytes Calcium transient Myofilament ATPase Contraction Reactive oxygen species Oxidative stress NADPH oxidase |
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