卒中后抑郁Nogo-P300的执行功能分析

目的通过事件相关电位检测,探讨卒中后抑郁患者的执行功能。方法对12例卒中后抑郁患者(观察组)及12例健康者(对照组)进行事件相关电位检测,受试者须对稀有声刺激执行按键反应(代表Go反应),对标准声刺激不执行按键反应(代表Nogo反应),通过头顶中央(Cz)记录大脑对听觉刺激信号产生的Nogo-P300波形,对Nogo-P300中的主成分Nogo-N2、Nogo-P3的波幅分别测量。结果观察组Nogo-N2、Nogo-P3波幅低于对照组,2组相比差别有统计学意义(P<0.01)。结论Nogo-N2、Nogo-P3显示反应抑制,可为卒中后抑郁提供执行功能的依据。

Executive function of Nogo-P300 in patients with post-stroke depression

Objective To investigate the execution function of patients with post-stroke depression by detecting event-related potential.Methods Event-related potential were detected in 12 post-stroke depression patients(observation group) and 12 healthy people(control group) subjects were required to press the key when they experience a rare acoustic stimulus(on behalf of Go response),and were not required to press the key when they experience a standard acoustic stimulus(on behalf of Nogo response).Nogo-P300 waveform from brain which response to auditory stimulation signal were recorded by the recording electrode,and the amplitudes of Nogo-N2 and Nogo-P3 were measured.Results The amplitudes of Nogo-N2 and Nogo-P3 in observation group were significantly lower than those in control group(P < 0.01).Conclusion The Nogo-N2 and the Nogo-P3 can showed executive function of patients with post-stroke depression.