基质金属蛋白酶抑制剂-1在口腔疣状癌中的表达研究

目的观察基质金属蛋白酶抑制剂(tissue inhibitor of metalloproteinase,TIMP)-1在口腔疣状癌(OVC)中的表达。方法选择15例口腔疣状癌、10例正常口腔黏膜、20例口腔鳞癌标本(高、低分化鳞癌各10例),应用免疫组化S-P法检测TIMP-1的表达和分布。结果口腔疣状癌组织中TIMP-1阳性表达率为80%(12/15),高于高分化鳞癌(60%,6/10)和低分化鳞癌(40%,4/10)(P<0.05);平均染色强度高于高、低分化鳞癌(P<0.05);口腔疣状癌、口腔高分化鳞癌、口腔低分化鳞癌组织中TIMP-1的表达均高于正常口腔黏膜组织(P<0.05)。结论OVC是一种不同于口腔鳞状细胞癌的独立类型的恶性肿瘤,TIMP-1可以抑制肿瘤的浸润与转移。

Expression of TIMP-1 in oral verrucous carcinoma

Objective To study the expression of tissue inhibitor of metalloproteinase(TIMP)-1 in oral verrucous carcinoma(OVC) and oral squamous cell carcinoma(SCC) so as to investigate their roles in the development of OVC and SCC.Methods 10 cases of normal oral mucosa(NM),15 cases of OVC and 20 cases of SCC were used to detect the expression of TIMP-1 by immunohistochemistry SP method.Results The TIMP-1 expression rate was 80% in OVC.It was higher than well differentiated squamous cell carcinoma(WDSCC)and poorly differentiated squamous cell carcinoma(PDSCC).The TIMP-1 expression rates of OVC,WDSCC and PDSCC were all higher than NM.Conclusion TIMP-1 may inhibit the transfer of the tumor.Meanwhile,it may suggest that OVC was an independent tumor.