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吡柔比星膀胱内灌注预防膀胱癌术后复发的临床研究
引用本文:孙祥宙,戴宇平,丘少鹏,邓春华,郑克立.吡柔比星膀胱内灌注预防膀胱癌术后复发的临床研究[J].临床肿瘤学杂志,2005,10(2):157-158,160.
作者姓名:孙祥宙  戴宇平  丘少鹏  邓春华  郑克立
作者单位:510080,广州,中山大学附属第一医院泌尿外科;510080,广州,中山大学附属第一医院泌尿外科;510080,广州,中山大学附属第一医院泌尿外科;510080,广州,中山大学附属第一医院泌尿外科;510080,广州,中山大学附属第一医院泌尿外科
摘    要:目的:探讨应用吡柔比星(THP)进行膀胱内灌注预防膀胱癌术后复发的疗效和安全性。方法:对68例初发的浅表性膀胱癌术后患者定期进行THP膀胱内灌注治疗,随访18—48个月。结果:全组无肿瘤复发率为85.3%,复发率为14.7%,29例于膀胱灌注期间出现膀胱刺激症状,其中4例因为不能耐受,暂停灌注,其余患者均完成治疗。所有患者未见明显的全身性药物反应。结论:THP膀胱内灌注预防膀胱癌术后复发的疗效满意,病人耐受性好,无全身性给药的毒副反应。

关 键 词:膀胱肿瘤  吡柔比星  膀胱灌注
文章编号:1009-0460(2005)02-0157-03
收稿时间:06 28 2004 12:00AM
修稿时间:2004-06-282004-09-21

Intravesical Instillation of Pirarubicin in the Prophylaxis of Local Recurrence after Resection of Bladder Cancer
SUN Xiang-zhou,Dai Yu-ping,QIU Shao-peng,DENG Chun-hua,ZHENG Ke-Li.Intravesical Instillation of Pirarubicin in the Prophylaxis of Local Recurrence after Resection of Bladder Cancer[J].Chinese Clinical Oncology,2005,10(2):157-158,160.
Authors:SUN Xiang-zhou  Dai Yu-ping  QIU Shao-peng  DENG Chun-hua  ZHENG Ke-Li
Institution:Department of Urology, The First Affiliated Hospital, Zhongshan University, Guangzhou 510060, China
Abstract:Objective:To investigate the effect of intravesical instillation of pirarubicin or mitomycin in the prophylaxis of local recurrence after resection of bladder cancer.Methods:68 patients with bladder cancer after TURBT or partial cystectomy received intravesical instillation of pirarubicin.All these patients were followed up for 18 to 48 months.Results:Recurrence rate in the patients treated with pirarubicin was 14.7%.No systemic side effect has been observed in all patients.Conclusion:Intravesical instillation of pirarubicin has been effective against local recurrence of bladder cancer without systemic side effects.
Keywords:Bladder neoplasms  Pirarubicin  Intravesical instillation
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