整合素与心血管疾病

细胞 -细胞之间以及细胞 -细胞外基质蛋白之间的正常粘附是细胞生长 ,分化以及迁移的基础 ,负责细胞内、外信号的传递 ,也是心血管系统所有组成成分维持功能正常的前提条件。因此 ,粘附功能异常在心血管疾病发病机制中也起着关键作用。目前为止 ,总共有 6个粘附分子家族 ,整合素 (ｉｎｔｅｇｒｉｎ)是细胞表面介导细胞 -细胞间以及细胞与细胞外基质粘附作用的粘附分子之一 ,与细胞的迁移、增殖和分化密切相关 ,是细胞信息传递的一个重要组成部分。整合素在维持血管正常结构和血管壁的通透性 ,防止血小板沉积和血栓形成 ,促进创伤愈合 ,以及…

Integrins and cardiovascular diseases

The adhesion of cells to each other and to the proteins of the extracellular matrix provides a stable environment for cell growth, differentiation and migration. This is a prerequisite for the normal function of the cardiovascular system. Thus the abnormal adhesion function may play a key role in the pathogenesis and development of cardiovascular diseases. To date, there are six main groups of adhesion molecule, and integrins family are the largest and most broadly distributed of the families of cellular adhesion receptors. They have an important role in several aspects of cardiovascular diseases and that its regulated inhibition leads to a reduction in incidence andmortality due to these disorders. This review focuses upon the structure, mechanism and their roles in cardiovascular diseases which maybe facilitate the development of novel therapies.