干细胞治疗心脏疾患研究进展

随着再生医学研究的深入，干细胞移植已用于临床实验。目前成骨骼肌细胞、骨髓源性干细胞、间充质干细胞和心肌固有干细胞已应用于心肌再生治疗。其中C-kit阳性心肌干细胞移植，不仅对收缩性心力衰竭有明确疗效，而且从长远来看，无明显不良事件发生。现就与心肌再生相关细胞作一综述，阐述何类细胞更适于心脏疾患的治疗。

Advances on stem cells in the treatment of cardiac diseases

Various researches on regenerative medicine were carried out experimentally, and selected modalities have been introduced to the clinical arena. So far skeletal myoblasts, bone marrow-derived cells, mesenchymal stromal cells, and resident cardiac cells have been applied for therapeutic myocardial regeneration. Among them, autologous transplantation of c-kit-positive cardiac stem cells in congestive heart failure patients resulted in an outstanding outcome, with long-lasting beneifcial effects without major adverse events. By reviewing these clinical trials, an endeavor was made to seek for an ideal cellular therapy for cardiovascular diseases.