消黄利胆汤对阻塞性黄疸患者外周血清炎症介质和Th1/Th2的影响

目的：观察自拟消黄利胆汤对阻塞性黄疸（OJ）患者外周血清炎症介质和辅助性T细胞1（Th1）/辅助性T细胞2（Th2）的影响。方法：选取90例OJ手术后患者按照术后不同治疗方法分为治疗组和对照组,每组各45例。治疗组采用自拟消黄利胆汤加减治疗,对照组给予术后常规治疗。连续治疗14d后比较两组患者外周血清炎症介质和Th1/Th2水平变化。结果：与治疗前比较,两组患者治疗后ET、TNF-α、IL-4、IL-6水平降低,IL-10水平升高（P〈0.05）,且治疗组的改善程度优于对照组（P〈0.05）;与治疗前比较,两组患者治疗后Th1/Th2比值显著增高,且治疗组的增高幅度大于对照组（P〈0.05）。结论：自拟消黄利胆汤可有效减轻阻塞性黄疸患者术后炎症和感染症状,并可以调节Th细胞免疫平衡,减轻肝损伤。

Influence of Xiaohuang Lidan Decoction on Peripheral Serum Inflammatory Mediators and Th1/Th2 of Patients with Obstructive Jaundice

Objective：To observe the influence of Self-made Xiaohuang Lidan Decoction on peripheral serum inflammatory mediators, helper T-cell（ Th1 ）/helper T-cell（Th2） of patients with obstructive jaundice. Methods ：90 cases of patients treated with OJ operation were divided into two groups according to treatment methods, each of 45 cases. The treatment group was treated with Self-made Xiao- huang Lidan Decoction, and the control group was given conventional treatment after operation. The peripheral serum inflammatory medi- ators and Th1/Th2 level change of two groups 14 days after treatment were compared. Results：ET,TNF-α,IL-6 and IL-4 levels reduc- tion and IL-10 level increase of two groups increased after treatment compared with that before treatment（ P 〈 0.05 ）. And the improve- ment of the treatment group was better than that of the control group（P 〈 0.05 ）. The proportion of Th1/Th2 of two groups after treat- ment evidently increased compared with that before treatment, and the increasing amplitude of the treatment group was greater than that of the control group（P 〈0.05）. Conclusion：Self-made Xiaohuang Lidan Decoction not only can evidently reduce postoperative inflam- mations and infections of patients with obstructive jaundice, but also can adjust immunologic balance of Th cells and reduce liver injury.