茵栀黄口服液治疗小儿黄疸临床研究

目的：观察茵栀黄口服液治疗小儿黄疸的疗效、安全性及其对血清微量元素水平的影响。方法：选取172例新生儿病理性黄疸患儿作为研究对象,将其随机分为观察组和对照组,每组各86例。对照组应用常规西医疗法,观察组在对照组疗法的基础上加用茵栀黄口服液,观察两组的临床疗效、治疗前后的血清总胆红素水平和铁、铜、锌离子的水平、黄疸消退时间以及药物不良反应。结果：观察组和对照组的临床有效率分别为100%（86/86）和80.2%（69/86）,观察组的临床有效率显著高于对照组（P〈0.05）,且观察组和对照组中疗效为＂显效＂的患儿比例分别为80.2%（69/86）和52.3%（45/86）,观察组中疗效为＂显效＂的患儿比例显著高于对照组（P〈0.05）;两组患儿治疗后的血清总胆红素浓度均较治疗前有显著下降（P〈0.05）,且观察组治疗后的血清总胆红素浓度显著低于对照组（P〈0.05）;观察组患儿的黄疸消退时间显著少于对照组（P〈0.05）;在观察组患儿中,有28例在治疗期间出现了轻度腹泻症状,占32.6%,主要表现为多次少量稀便或稀水样便,经对症治疗后症状得到改善,两组均未发现其他严重的药物不良反应;两组患儿的血清铁、铜、锌离子水平显著下降（P〈0.05）,且观察组的下降幅度显著大于对照组（P〈0.05）。结论：茵栀黄口服液辅助治疗小儿黄疸的临床疗效更好,能够更加显著地降低患儿血清总胆红素水平,加快黄疸的消退,纠正微量元素代谢紊乱,降低血清微量元素水平。

Clinical Research on Yinzhihuang Oral Liquid Treatment of Pediatric Jaundice

Objective：To observe and analyze the efficacy, safety and effects on the trace elements of Yinzhihuang oral liquid in treatment of children with pediatric pathological jaundice. Methods ：172 cases of neonatal pathological jaundice were selected as the research ob- jects and randomly divided into the observation group and the control group. 86 cases were included into each group. The patients in the control group were treated with the conventional western medicine treatments, while the patients in the observation group were treated with the therapy of the control group combined with Yinzhihuang oral liquid. The clinical curative effects ,the serum levels of total biliru- bin, iron ion, copper ion, zinc ion before and after the treatment, the time for jaundice to regress and the drug adverse reactions of the two groups were observed and compared. Results：After treatment, the clinical efficiency of the observation group and the control group were 100% （86/86） and 80.2% （69/86） respectively, the clinical efficiency of the observation group was significantly higher than that of the control group （ P 〈 0.05 ） , and the proportion of the patients with magnificent effects in the observation group and the control group were 80.2% （69/86） and 52.3% （45/86） ,the proportion of the patients with magnificent effects in the observation group was signifi- cantly higher than that in control group （ P 〈 0.05 ） ; the serum total bilirubin levels of two groups after treatment decreased significantly compared with those before the treatment （ P 〈 0.05 ）, and the serum total bilirubin level of the observation group after the treatment were significantly lower than that of the control group（ P 〈 0.05 ） ;the time for jaundice to regress of the observation group was signifi- cantly shorter than that of the control group（ P 〈 0.05 ） ; in the observation group,28 cases of mild diarrhea were observed during the treatment,accounting for 32.6% of all the cases of the observation group, mainly for many small stools or watery stool. The symptoms improved after symptomatic treatment and no other serious drug adverse reactions were observed in the two groups. The serum iron, cop- per, zinc levels of the children in the two groups decreased significantly（ P 〈 0.05 ）, and the levels of the observation group decreased more significantly than the control group（ P 〈 0. 05 ）. Conclusion ：The therapeutic effect of Yinzhihuang oral liquid adjuvant treatment ofthe children with pediatric jaundice is better. The treatment can significantly reduce the serum total bilirubin levels, accelerate the jaun- dice regression, correct the abnormality of trace element metabolism, reduce the levels of the serum trace elements, which has high safety and worthy of clinical application.