慢性肝病和肝癌中HCV核心区三种寡肽抗原的抗体检测

检测１４８例慢性肝病和肝癌患者血清中丙型肝炎病毒核心区３种寡肽抗原的抗体，结果显示其阳性率在慢性迁延型肝炎、慢性活动型肝炎、肝炎肝硬化和原发性肝癌患者分别为７．７％，２３．１％，，２３．５％和１６．３％。在抗体阳性者中８０％以上有乙型肝炎病毒感染证据，提示我国ＨＢＶ和ＨＶＣ重叠感染较为常见。

Antibodies Against Three Oligopeptides from Core Region of HCV in Patients with Chronic Liver Diseases and Primary Hepatocellualr Carcinoma

Antibodies against three oligopeptides from the core region of HCV(CP9,CP10,CP14) were detected in 148 patients with chronic liver diseases and primary hepatocellular carcinoma(PHC).The positive rates of these antibodies were 7.7%, 23.1%,23.5% and 16.3% in cases of chronic persistent hepatitis(CPH),chronic active hepatitis(CAH),hepatitis liver cirrhosis(HLC)and PHC respectively. More than 80% of patients positive for antibodies to core peptides of HCV had serological evidence of HBV infection indicating that super-infection of HCV in patients with hepatitis B was relatively common. In PHC group 95.9% of cases had serological markers of HBV infection while only 4.1% had antibodies to core peptides of HCV alone; This finding:snggests that HBV may be the major virological factor accounted for PHC.