Effect of bilobalide B on cholinergic hippocampal neurons exposed to cholesterol and apolipoprotein E4 |
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| Authors: | Xijuan Jiang Bin Lu Yingchang Fan |
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| Affiliation: | Xijuan Jiang1,Bin Lu2,Yingchang Fan11Department of Pathology,Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China 2Department of Experiment , Teaching,China |
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| Abstract: | BACKGROUND: Extracts of ginkgo biloba leaves have been reported to improve nerve function and activ- ity in Alzheimer's disease, which is associated with reduced secretion of cholinergic neurotransmitter in hip- pocampal neurons. OBJECTIVE: To validate the protective effect of bilobalide B against in vitro injury of cholinergic neurons of the hippocampus induced by combined cholesterol and apoE4 DESIGN, TIME AND SETTING: This randomized, controlled animal experiment was performed in the Pathology Laboratory... |
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