己酮可可碱对体外精子活力的影响

目的：研究己酮可可碱（Pentoxifyline,PTF)对弱精患者精子活力的影响，探讨PTF提高精子活力的作用机理。方法：采用计算机辅助精子分析（CASA）系统，以同一份精液标本为自身对照，测定PTF处理前后精子活力参数值，结果：PTF处理后精子活力（a b级）显著提高（P＜0．01），对提高快速前向运动精子活力（a级）有极显著意义（P＜0．005），而对精子活动率的提高不显著（P＞0．05），PTF对活动力较好精子活力的提高活力的提高不及活动力差的明显（P＜0．05），结论：PTF能有效提高弱精患者精子活力。

THE EFFECT OF PENTOXIFYLLINE ON THE SPERM MOTILITY IN VITRO

OBJECTIVE:To study the effect of pentoxifylline(PTF) on the sperm motility of asthenozoospermic patients and to explore the mechanism to improve the sperm motility.METHODS:We used CASA system to measure the parameters of the sperm motility which was treated with PTF in vitro compared with the untreated controls.RESULTS:The addition of PTF significantly increased the percentage of forwardly progressive spermatozoa(rate a b) ( P <0.01),especially the percentage of fast forwardly progressive spermatozoa(rate a) ( P <0.005); The improvement of the percentage of non motile spermatozoa was not remarkable(rate d)( P >0.05);The increased rate of sperm motility of poor motile spermatozoa was more obviously than that of well motile spermatozoa( P <0.05).CONCLUSION:PTF can improve the sperm motiltiy of asthenozoospermic patients effectively.