一氧化氮及合成酶在缺氧缺血性脑病中的探讨

目的 探讨一氧化氮、一氧化氮合成酶在新生儿缺氧缺血性脑病的病情、预后中的作用及临床意义。方法 HIE组及对照组均于出生24h内用分光光度计比色法测定NO、NOS。结果 中、重度H匝E急性期NO、NOS水平较正常新生儿明显升高。结论 NO、NOS水平高低与HIE患儿脑损伤严重程度有关，可作为判断病情、预后的指标。

Observation of the Level of NO and NOS in HIE

Objective explore the function and clinic significance of NO and NOS in HIE severity and prognosis.Methods NO and NOS were measured by both in HIE groups and control groups within 24h of born.Results in acute phase,the NO and NOS levels in infants with moderate and severe HIE were much higher than normal newborn infants.Conclusion the level of NO and NOS has relation to the degree of hrain damage of HIE,It can evaluate the severity of the disease and its prognosis.