Voltage-sensitive Na channels increase in number in newborn rat brain after in utero hypoxia |
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Authors: | Ying Xia Gabriel G. Haddad |
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Abstract: | The effect of chronic in utero hypoxia on voltage-sensitive Na+ channels in newborn rat brain was investigated by means of ligand binding and autoradiography with [3H]saxitoxin (STX,na+ channel ligand). We found that: (a) binding properties were different between hypoxic and control brains with alinear Scatchard plots in hypoxic brain versus linear ones in the control; (b) STX binding density increased greatly in response to hypoxic stimulation; and (c) the hypoxia-induced increase in STX binding was heteregneous in various brian areas. We conclude that hypoxia in utero alters the expression of Na+ channels and induces an up-regulation of Na+ channel density as a function of brain area. This is the first report of this phenomenon and we believe that the increased Na+ channels may play an important role in the etiology of neurological disorders such as epilepsy. |
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Keywords: | Chronic hypoxia Immature brain Receptor Regulation Saxitoxin Sodium channels |
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