Bcl -2和PD -L1在大肠癌组织中的表达及两者与大肠癌侵袭转移的相关性

目的 分析Bcl -2及PD - L1在大肠癌中的表达并探讨其与大肠癌临床病理特征之间的关系,及与大肠癌侵袭转移的相关性.方法 用免疫组化法检测57例手术切除大肠癌组织新鲜标本及癌旁正常黏膜组织中Bcl -2及PD - L1的表达,并结合临床病理特征进行相关性分析.结果 ①与癌旁正常组织相比,Bcl -2及PD - L...

Expression of Bcl- 2 and PD- L1 in colorectal cancer and the correlation of the two factors with invasion and metastasis

Objective To study the expression of Bcl-2 and PD-L1 in colorectal cancer tissue,and to investigate their relationship with clinical pathological features and the correlation with invasion and metastasis of colorectal cancer.Methods Bcl-2 and PD-L1 were detected immunohistochemically in 57 cases of colorectal cancer tissue specimens and normal tissue samples,then correlation analysis were taken combined with clinical and pathological features.Results ①The positive expression rates of Bcl-2 and PD-L1 in colorectal cancer tissues were higher than their expression in normal mucosa tissues,and there were significant differences-（P0.05）.②The expression of BCL-2 and PD-L1 in colorectal cancer with the high and the moderately-differentiated group were significantly increased compared with the poorly-differentiated group,there was significant difference（P0.01）.The positive expression rate of PD-L1 in colorectal cancer patients with lymph node metastasis（Dukes stage C＋D） was elevated significantly compared to the group without lymph node metastasis（Dukes stage A＋B）（P0.05）.③In the high-and the moderately-differentiated colorectal cancer,Bcl-2 expression rate in PD-L1 negative group was higher than that in PD-L1 positive group,there was significant difference（P0.01）.Conclusions The detection of Bcl-2 and PD-L1 expression in colorectal cancer can help determine the ability of invasion and metastasis and may have important clinical significance for the diagnosis,treatment and prognosis judgment of colorectal cancer.