Acute ST-elevation myocardial infarction in two young women with cystic fibrosis and cystic fibrosis-related diabetes |
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| Affiliation: | 1. Division of Endocrinology & Metabolism, University of North Carolina, Chapel Hill, NC, United States;2. Department of Internal Medicine, University of North Carolina, Chapel Hill, NC, United States;3. Division of Pulmonary Diseases and Critical Care Medicine, University of North Carolina, Chapel Hill, NC, United States;4. Division of Pediatric Pulmonology, University of North Carolina, Chapel Hill, NC, United States;1. Consultant in Paediatric Respiratory Medicine, Noah''s Ark Children''s Hospital for Wales, Cardiff, UK;2. Consultant in Paediatric Respiratory Medicine, Cardiff University School of Medicine, Cardiff, UK;1. Department of Pediatrics, Division Pulmonology CB#7217 University of North Carolina, Chapel Hill, NC 27599-7217, United States;2. Marsico Lung Institute, 130 Mason Farm Rd. CB #7020 UNC-CH Chapel Hill NC 27599-7020. United States;3. Department of Biostatistics, University of North Carolina, 170 Rosenau Hall, CB #7400, 135 Dauer Drive, Chapel Hill, NC 27599-7400, United States;4. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland;5. Center for Disease Dynamics, Economics & Policy, Washington, DC;6. Department of Pediatrics, Columbia University Irving Medical Center, New York, 622 W 168th St, New York, NY 10032, United States;7. Department of Infection Prevention & Control, NewYork-Presbyterian Hospital, New York, 622 W 168th St, New York, NY 10032, United States;1. School of Biomedical Sciences, Ulster University, Cromore Road, Coleraine, Co. Londonderry, Northern Ireland, BT52 1SA, UK,;2. Northern Ireland Regional Adult Cystic Fibrosis Centre, Level 8, Belfast City Hospital, Lisburn Road, Belfast, Northern Ireland, BT9 7AB, UK,;3. Laboratory for Disinfection and Pathogen Elimination Studies, Northern Ireland Public Health Laboratory, Belfast City Hospital, Lisburn Road, Belfast, Northern Ireland, BT9 7AD, UK.;1. QIMR Berghofer Medical Research Institute, Brisbane, Australia;2. School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia;3. Faculty of Medicine, The University of Queensland, Brisbane, Australia;4. Department of Respiratory and Sleep Medicine, Queensland Children''s Hospital, Brisbane, Australia;5. School of Medicine and Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia;6. Departments of Infectious Diseases and Paediatrics, Gold Coast Health, Gold Coast, Australia;7. UQ Centre for Clinical Research, The University of Queensland, Brisbane, Australia;8. Pathology Queensland Central Laboratory, Brisbane, Australia;9. Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, Australia;10. Australian Centre for Ecogenomics, The University of Queensland, Brisbane, Australia;11. Department of Thoracic Medicine, The Prince Charles Hospital, Brisbane, Australia;1. Department of Pediatrics, University of Washington, Seattle, WA 98195, USA;2. Children''s Core for Biostatistics, Epidemiology and Analytics in Research, Seattle Children''s Research Institute, Seattle, WA 98101, USA;3. Department of Genetic Medicine, Johns Hopkins University, Baltimore, MD 21287, USA;4. Division of Pediatric Endocrinology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA;5. Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195, USA;6. Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA;7. Marsico Lung Institute/Cystic Fibrosis Research Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA;8. Bioinformatics Research Center and Department of Statistics, North Carolina State University, Raleigh, NC 27695, USA;9. Department of Biological Sciences, North Carolina State University, Raleigh, NC 27695, USA;10. Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA;11. Division of Genetic Medicine, Seattle Children''s Hospital, Seattle, WA 98105, USA;1. National Heart & Lung Institute, Imperial College London, UK;2. Royal Brompton and Harefield Hospitals, London, UK;3. Department of Infectious Diseases, Imperial College London, UK;4. Department of Medicine, Queen''s University Belfast, UK |
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| Abstract: | Ischemic heart disease is rarely reported in people with cystic fibrosis (PwCF) despite multiple potential risk factors. Here we report two cases of ST elevation myocardial infarction (STEMI), both in young women with cystic fibrosis (CF) and cystic fibrosis related diabetes (CFRD). These cases illustrate the importance of considering myocardial injury/infarction in the differential diagnosis of patients with CF and chest pain or shortness of breath, and addressing the growing risk of cardiovascular disease (CVD). |
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