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Disease burden in people with cystic fibrosis heterozygous for F508del and a minimal function mutation
Affiliation:1. Boston Children''s Hospital, Harvard Medical School, Boston, MA, USA;2. Vertex Pharmaceuticals Incorporated, Boston, MA, USA;3. ICON Clinical Research, North Wales, PA, USA;4. Rainbow Babies and Children''s Hospital, Case Western Reserve University School of Medicine, Cleveland, OH, USA;5. Medical University of South Carolina, Charleston, SC, USA;1. School of Biomedical Sciences, Ulster University, Cromore Road, Coleraine, Co. Londonderry, Northern Ireland, BT52 1SA, UK,;2. Northern Ireland Regional Adult Cystic Fibrosis Centre, Level 8, Belfast City Hospital, Lisburn Road, Belfast, Northern Ireland, BT9 7AB, UK,;3. Laboratory for Disinfection and Pathogen Elimination Studies, Northern Ireland Public Health Laboratory, Belfast City Hospital, Lisburn Road, Belfast, Northern Ireland, BT9 7AD, UK.;1. Department of Pediatrics, Division of Pediatric Pulmonology, Children''s Hospital Los Angeles, Keck School of Medicine, University of Southern California, 4650 Sunset Blvd, MS 83, Los Angeles, California, USA;2. Division of Pulmonary Medicine, Cincinnati Children''s Hospital Medical Center, Cincinnati, Ohio, USA;3. Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA;1. Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA;2. School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada;3. Center of Excellence in Pulmonary Biology, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, USA;4. Department of Pediatric Pneumology, Immunology and Intensive Care Medicine, CF Center, Charité-Universitätsmedizin Berlin, Berlin, Germany;5. Centre for Heart Lung Innovation, University of British Columbia and St. Paul''s Hospital; Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, BC, Canada;1. National Heart & Lung Institute, Imperial College London, UK;2. Royal Brompton and Harefield Hospitals, London, UK;3. Department of Infectious Diseases, Imperial College London, UK;4. Department of Medicine, Queen''s University Belfast, UK;1. Department of Health Services, University of Washington, Seattle, Washington, United States;2. School of Pharmacy, University of Washington, Seattle, Washington, United States;3. Department of Radiology, University of Washington, Seattle, Washington, United States;4. Department of Medicine, University of Washington, Seattle, Washington, United States;5. Department of Pediatrics, University of Washington, Seattle, Washington, United States;6. Department of Medicine, Johns Hopkins University, Baltimore, Maryland, United States;1. Poznan University of Medical Sciences, Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan, Poland;2. Poznan University of Medical Sciences, Department of Cardiology-Intensive Therapy, Poznan, Poland;3. Poznan University of Medical Sciences, Department of Physiology, Poznan, Poland;4. Poznan University of Medical Sciences, Department of Bromatology, Poznan, Poland;5. Poznan University of Medical Sciences, Department of Pediatric Pneumonology, Allergology and Clinical Immunology, Poznan, Poland;6. Poznan University of Medical Sciences, Department of Pulmonology, Allergology and Respiratory Oncology, Poznan, Poland;7. West Kazakhstan Marat Ospanov Medical University, Department of Natural Sciences Disciplines, Aktobe, Kazakhstan;8. Research Centre for Medical Genetics, Department of Genetic Epidemiology, Cystic Fibrosis Group, Moscow, Russia
Abstract:
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