Incidence,risk and protective factors of symptoms after colonoscopy |
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| Affiliation: | 1. Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy;2. Stony Brook Cancer Center, Stony Brook University, Stony Brook, NY, United States;3. Gastroenterology Unit, Valduce Hospital, Como, Italy;4. Digestive Endoscopy Unit, Centro Traumatologico-Ortopedico Hospital, Iglesias, Italy;5. Division of Gastroenterology and Digestive Endoscopy, Department of Gastroenterology, IRCCS Humanitas Research Hospital, via Manzoni 56, 20089 Rozzano, Milan, Italy;6. Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20072 Pieve Emanuele, Milan, Italy;7. IRCCS Azienda Ospedaliero-Universitaria di Bologna, Department of Medical and Surgical Sciences, Gastroenterology Unit, University of Bologna, Bologna, Italy;8. Digestive Endoscopy Unit, Division of Gastroenterology, Humanitas Clinical and Research Center, Milan, Italy;9. Endoscopy Service, AUSL Reggio Emilia, Reggio Emilia, Italy;10. IBD Unit, Gastroenterology Department, Careggi Hospital, University of Florence, Viale San Luca, 50134, Florence, Italy;11. Unit of Gastroenterology and Digestive Endoscopy, Forli-Cesena Hospital, AUSL Romagna, Forli-Cesena, Italy;12. Division of Endoscopy, Istituto di Ricovero e Cura a Carattere Scientifico, European Institute of Oncology, Milan, Italy;13. Azienda Ospedaliera Regionale “S. Carlo”, Potenza, Italy;14. Gastroenterology Unit, S. Maria delle Croci Hospital, Ravenna, Italy;15. Città della Salute e della Scienza, Turin, Italy;p. UOSD Gastroenterologia ed Endoscopia Digestiva, Azienda USL di Modena, Italy;q. Interventional Endoscopy ASST Monza, Monza, Italy;1. Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy;2. Stony Brook Cancer Center, Stony Brook University, Stony Brook, NY, United States;3. Gastroenterology Unit, Valduce Hospital, Como, Italy;4. Digestive Endoscopy Unit, Centro Traumatologico-Ortopedico Hospital, Iglesias, Italy;5. Division of Gastroenterology and Digestive Endoscopy, Department of Gastroenterology, IRCCS Humanitas Research Hospital, via Manzoni 56, 20089 Rozzano, Milan, Italy;6. Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20072 Pieve Emanuele, Milan, Italy;7. IRCCS Azienda Ospedaliero-Universitaria di Bologna, Department of Medical and Surgical Sciences, Gastroenterology Unit, University of Bologna, Bologna, Italy;8. Digestive Endoscopy Unit, Division of Gastroenterology, Humanitas Clinical and Research Center, Milan, Italy;9. Endoscopy Service, AUSL Reggio Emilia, Reggio Emilia, Italy;10. IBD Unit, Gastroenterology Department, Careggi Hospital, University of Florence, Viale San Luca, 50134, Florence, Italy;11. Unit of Gastroenterology and Digestive Endoscopy, Forli-Cesena Hospital, AUSL Romagna, Forli-Cesena, Italy;12. Division of Endoscopy, Istituto di Ricovero e Cura a Carattere Scientifico, European Institute of Oncology, Milan, Italy;13. Azienda Ospedaliera Regionale “S. Carlo”, Potenza, Italy;14. Gastroenterology Unit, S. Maria delle Croci Hospital, Ravenna, Italy;15. Città della Salute e della Scienza, Turin, Italy;p. UOSD Gastroenterologia ed Endoscopia Digestiva, Azienda USL di Modena, Italy;q. Interventional Endoscopy ASST Monza, Monza, Italy |
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| Abstract: | BackgroundFew studies focused on minor adverse events which may develop after colonoscopy.AimsTo investigate the incidence and factors associated to post-colonoscopy symptoms.MethodsThis is a prospective study conducted in 10 Italian hospitals. The main outcome was a cumulative score combining 10 gastrointestinal (GI) symptoms occurring the week following colonoscopy. The analyses were conducted via multivariate logistic regression.ResultsOf 793 subjects included in the analysis, 361 (45.5%) complained the new onset of at least one GI symptom after the exam; one symptom was reported by 202 (25.5%), two or more symptoms by 159 (20.1%). Newly developed symptoms more frequently reported were epigastric/abdominal bloating (32.2%), pain (17.3%), and dyspeptic symptoms (17.9%). Symptoms were associated with female sex (odds ratio [OR]=2.54), increasing number of symptoms developed during bowel preparation intake (OR=1.35) and somatic symptoms (OR=1.27). An inverse association was observed with better mood (OR=0.74). A high-risk profile was identified, represented by women with bad mood and somatic symptoms (OR=8.81).ConclusionAbout half of the patients develop de novo GI symptoms following colonoscopy. Improving bowel preparation tolerability may reduce the incidence of post-colonoscopy symptoms, especially in more vulnerable patients. |
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