The role of B cells and their interactions with stromal cells in the context of inflammatory autoimmune diseases |
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| Institution: | 1. Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands;2. Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands;1. Department of Internal Medicine - Multi-Organic Diseases, Local Referral Center for Rare Auto-immune Diseases, Montpellier University Hospital, Montpellier, France;2. Department of nephrology, Université de Montpellier, CHU de Montpellier, Montpellier, France.;3. Department of Epidemiology and Biostatistics, Montpellier University Hospital, Montpellier, France;4. Department of Rheumatology, Montpellier University Hospital, University of Montpellier, PhyMedExp, University of Montpellier, INSERM U1046, CNRS UMR, 9214 Montpellier, France;5. Department of Neurology, University Hospital of Montpellier, Montpellier, France;6. Internal Medicine Department, Nîmes University Hospital, Montpellier University, Nîmes, France;7. Institute of Regenerative Medicine and Biotherapy, Institut national de la santé et de la recherche médicale U1183, Montpellier, France;1. ARUP Laboratories, Salt Lake City, UT, United States of America;2. Department of Pathology, University of Utah, Salt Lake City, UT, United States of America;3. Department of Internal Medicine, Division of Rheumatology, University of Utah, Salt Lake City, UT, United States of America;1. Universitat Autònoma de Barcelona, Barcelona, Spain;2. Systemic Autoimmune Research Unit, Vall d''Hebron Institut de Recerca, Barcelona, Spain;3. Systemic Autoimmune Diseases Unit, Department of Internal Medicine, Vall d''Hebron University Hospital, Barcelona, Spain;4. Department of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain;1. Renal Division, Department of Health Sciences, Università degli Studi di Milano, Milano, Italy;2. Neuroscience Section, Dino Ferrari Centre, Department of Pathophysiology and Transplantation, University of Milan, Milano, Italy;3. Independent Researcher, Milano, Italy;1. Department of Neurology and Center of Clinical Neuroscience, Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic;2. Centre for Rheumatology Research, Division of Medicine, University College London, Rayne Building, London WC1E 6JF, United Kingdom;3. Third Department of Internal Medicine, Department of Endocrinology and Metabolism, Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic;4. Department of Pharmaceutical Sciences and Neurology, University at Buffalo, State University of New York, Buffalo, NY, USA;5. Department of Physiotherapy, Faculty of Health Care, University of Presov, Slovak Republic |
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| Abstract: | Interactions between B cells and stromal cells have essential functions in immune cell development and responses. During chronic inflammation, the pro-inflammatory microenvironment leads to changes in stromal cells, which acquire a pathogenic phenotype specific to each organ and disease. B cells are recruited to the site of inflammation and interact with these pathogenic stromal cells contributing to the disease’s severity. In addition to producing autoantibodies, B cells contribute to the pathogenesis of autoimmune inflammatory diseases by serving as professional antigen-presenting cells, producing cytokines, and through additional mechanisms. This review describes the role of B cells and their interactions with stromal cells in chronic inflammation, with a focus on human disease, using three selected autoimmune inflammatory diseases: rheumatoid arthritis, systemic lupus erythematosus and multiple sclerosis. Understanding B cells roles and their interaction with stromal cells will help develop new therapeutic options for the treatment of autoimmune diseases. |
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