Dapoxetine and the treatment of premature ejaculation |
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Authors: | Premsant Sangkum Rhamee Badr Ege Can Serefoglu Wayne JG Hellstrom |
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Institution: | 1.Department of Urology, Tulane University Health Sciences Center, New Orleans, LA, USA;;2.Department of Urology, Bagcilar Training & Research Hospital, Istanbul, Turkey |
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Abstract: | BackgroundPremature ejaculation (PE) is the most common male sexual complaint. Off-label oral selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed for the treatment of PE. Dapoxetine is a short-acting SSRI specifically designed for on-demand use. The objective of this communication is to summarize the clinical and physiological evidence regarding the role of the serotonergic pathway and specifically dapoxetine in the treatment of PE.MethodsA PubMed search was conducted on articles reporting data on dapoxetine for the treatment of PE. Articles describing the pathophysiology and treatment options for PE were additionally included for review.ResultsThe etiology of PE is multi-factorial in nature. There are many treatment options for PE such as psychological/behavioral therapy, topical anesthetic agents, phosphodiesterase type 5 (PDE-5) inhibitors, and tramadol hydrochloride. SSRIs play a major role in PE treatment. Animal and clinical studies in addition to its pharmacokinetic document dapoxetine’s clinical efficacy and safety for on-demand treatment of PE.ConclusionsDapoxetine demonstrates clinical efficacy and a favorable side effect profile. Dapoxetine is currently the oral drug of choice for on-demand treatment of PE. |
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Keywords: | Dapoxetine premature ejaculation (PE) selective serotonin reuptake inhibitor (SSRI) |
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