Inflammation induced by Bothrops asper venom |
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Authors: | Catarina Teixeira Yara Cury Gisele Picolo |
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Affiliation: | a Laboratório de Farmacologia, Instituto Butantan, Av. Vital Brazil, 1500 - CEP 05503-900 - Sao Paulo, SP, Brazil b Laboratório de Fisiopatologia, Instituto Butantan, Sao Paulo, Brazil c Facultad de Microbiología, Instituto Clodomiro Picado, Universidad de Costa Rica, San José, Costa Rica |
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Abstract: | Inflammation is a major characteristic of envenomation by snakes from viperine and crotaline species. Bothrops asper snake venom elicits, among other alterations, a pronounced inflammatory response at the site of injection both in humans and experimental animals. This review describes the current status of our understanding of the inflammatory reaction, including pain, triggered by Bothrops asper venom. The experimental studies on the action of this venom as well as the complex network of chemical mediators involved are summarized. Moreover, aspects of the molecular mechanisms orchestrating this important response to envenomation by Bothrops asper are presented. Considering that isolated toxins are relevant tools for understanding the actions of the whole venom, studies dealing with the mechanisms of inflammatory and nociceptive properties of phospholipases A2, a metalloproteinase and serine-proteases isolated from Bothrops asper venom are also described. |
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Keywords: | Bothrops asper Venom Inflammation Pain Toxins |
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