| 中丝蛋白在脑膜和脑膜瘤上的表达 |
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| 引用本文： | 张惠铭,朱桂彬,邱铁东,于洪藻,杨相林,付长春,崔丽英,金友南,张元德.中丝蛋白在脑膜和脑膜瘤上的表达[J].吉林大学学报(医学版),1992(2). |
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| 作者姓名： | 张惠铭 朱桂彬 邱铁东 于洪藻 杨相林 付长春 崔丽英 金友南 张元德 |
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| 作者单位： | 白求恩医科大学基础医学院病理解剖教研室
(张惠铭，朱桂彬，邱铁东，于洪藻，杨相林)，白求恩医科大学第一临床医学院病理科
(付长春，崔丽英，金友南)，白求恩医科大学第一临床医学院病理科(张元德) |
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| 摘 要： | 本文以免疫组化方法研究了中丝蛋白在正常脑膜(蛛网膜颗粒)和脑膜瘤上的表达。脑膜细胞不仅表达了波形蛋白,而且表达了角蛋白、反应了其间皮和上皮的特性。4例上皮型脑膜瘤共同表达了波形蛋白和角蛋白,显示其双相的分化。由于脑膜和脑膜瘤有共同的中丝蛋白表达特征,我们认为脑膜瘤来自脑膜细胞的异常增生。
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| 关 键 词： | 脑膜 脑膜瘤 中丝蛋白 分化免疫组织化学 |
EXPRESSION OF INTERMEDIATE FILAMENT PROTEINS IN MENINGES AND MENINGIOMA |
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| Zhang Huiming,et al.EXPRESSION OF INTERMEDIATE FILAMENT PROTEINS IN MENINGES AND MENINGIOMA[J].Journal of Jilin University: Med Ed,1992(2). |
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| Authors: | Zhang Huiming |
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| Institution: | Department of Pathology |
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| Abstract: | Normal meningial cells (arachnoid granulation) and meningiomas were studied for their expression of intermediate filament proteins by immunohistochemical technique. Meningial cells expressed not only vimentin filament, but also keratin. This reflected their mesenchymal and epithelial characteristics. Meningiomatous cells, including epithelioid. fibroid transitive and angioblas-tic cells exhibited positive reaction to vimentin. On the other hand, four epithelial meningiomas expressed both vimentin and keratin. This reflected their biphasic differentiation. Since the meninges and meningioma possessed the same characteristics in expression of intermediate filament proteins. we consider that meningioma are derived from abnormal hyperplasia of the meningial cells. |
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| Keywords: | Meninges Meningioma Intermediate filament protein Differentiation Immuno-histochemistry |
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