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阴阳透刺法对急性脑梗死患者t-PA及PAI-1的影响
引用本文:欧阳泠星,吴远华,苏红梅,吴邦启,朱广旗.阴阳透刺法对急性脑梗死患者t-PA及PAI-1的影响[J].上海针灸杂志,2009,28(9):504-506.
作者姓名:欧阳泠星  吴远华  苏红梅  吴邦启  朱广旗
作者单位:1. 广东省清远市中医院,广东,511500
2. 贵阳中医学院第一附属医院,贵州,550002
3. 山东临沂市人民医院,山东,276003
4. 天津中医药大学第一附属医院,天津,300193
摘    要:目的观察阴阳透刺法对急性脑梗死患者的组织型纤溶酶原激活剂(t—PA)、其抑制物组织型纤溶酶原激活物抑制剂(PAI-1)的影响,探讨针刺治疗缺血性脑血管病可能的作用机制。方法将80例急性脑梗死患者分为治疗组和对照组各40例。分别观察治疗前、治疗后血浆t—PA、PAI-1的活性,并与正常组40例进行对照。结果治疗前,两组t—PA的活性较明显低下,相反,PAI-1的活性明显增高,与正常组比较差异有统计学意义(P〈0.01)。治疗后,两组t—PA的活性各与其自身治疗前比较明显增强,而PAI-1活性各与其自身治疗前比较明显降低(P〈0.01,P〈0.05),且治疗后两组间t—PA及PAI-1活性比较差异有统计学意义(P〈0.05)。结论治疗前,急性脑梗死患者t—PA活性明显低下和PAI-1活性明显增高,阴阳透刺法可降低PAI-1活性和增高t—PA活性,调节纤溶功能,促进溶解血栓,确为临床针刺治疗急性脑梗死的一种较可靠治疗方法。

关 键 词:针刺  透刺  脑梗死  组织型纤溶酶原激活剂  组织型纤溶酶原激活物抑制剂

Study of the Influence of Yin-yang Penetration Needling Method on T-PA and PAI-1 in Patients with Acute Cerebral Infarction
OUYANG Ling-xing,WU Yuan-hua,SU Hong-mei,WU Bang-qi,ZHU Guang-qi.Study of the Influence of Yin-yang Penetration Needling Method on T-PA and PAI-1 in Patients with Acute Cerebral Infarction[J].Shanghai Journal of Acupuncture and Moxibustion,2009,28(9):504-506.
Authors:OUYANG Ling-xing  WU Yuan-hua  SU Hong-mei  WU Bang-qi  ZHU Guang-qi
Institution:OUYANG Ling-xing, WU Yuan-hua, SU Hong-mei, WU Bang-qi, Supervisor ZHU Guang-qi( 1.Guangdong Qingyuan Hospital of Traditional Chinese Medicine,Guangdong 511500,China; 2.First Hospital Affiliated to Guiyang College of Traditional Chinese Medicine,Guizhou 550002,China; 3. Shandong Linyi People's Hospital,Shandong 276003,China; 4.First Hospital Affiliated to Tianjing University of Traditional Chinese Medicine,Tianjing 300193,China)
Abstract:Objective To investigate the possible mechanism of therapeutic action of acupuncture on ischemic cerebrovascular disease by observing the influence of yin-yang Penetration needling method on tissue type plasminogen activator (t-PA) and a substance that inhibits it, tissue type plasminogen activator inhibitor (PAI-1) in patients with acute cerebral infarction. Methods Eighty patients with acute cerebral infarction were randomly allocated to treatment and control groups, 40 cases each. Plasma t-PA and PAI-1 a...
Keywords:Acupuncture  Penetration needling method  Cerebral infarction  Tissue type plasminogen activator  Tissue type plasminogen activator inhibitor  
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