Bartter syndrome in a neonate: early treatment with indomethacin |
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Authors: | C. C. Mourani S. A. Sanjad C. Y. Akatcherian |
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Affiliation: | H?tel-Dieu de France Hospital, Department of Pediatrics and Pediatric Hemodialysis Unit, PO Box 16-6830, Beirut, Lebanon e-mail: mourani@ inco.com.lb, Fax: +961-1-686271, FR American University Medical Center, Department of Pediatrics, Beirut, Lebanon, LB
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Abstract: | The neonatal form of Bartter syndrome is characterized by intrauterine onset of polyuria leading to severe polyhydramnios. We report a patient with the early onset of the syndrome and a similar history in a previous sibling who died in early neonatal life. The patient is a female product of 33 weeks of gestation complicated by severe polyhydramnios. Her birth weight was 2,100 g. Polyuria led to severe dehydration on the 3rd day of life. Laboratory studies showed hypokalemia, hyponatremia, and elevated plasma levels of renin and aldosterone. Hypercalciuria was associated with echographic evidence of nephrocalcinosis. Indomethacin therapy resulted in a significant reduction in urine volume and correction of biochemical abnormalities. Growth and development are satisfactory after 4 years of indomethacin therapy, but nephrocalcinosis remains unchanged. Received: 22 December 1998 / Revised: 13 May 1999 / Accepted: 1 June 1999 |
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Keywords: | Neonatal Bartter syndrome Indomethacin Hypercalciuria Nephrocalcinosis |
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