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Vascular endothelial growth factor in exercising humans under different environmental conditions |
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| Authors: | Hanns-Christian Gunga Karl Kirsch Lothar Röcker Claus Behn Eberhard Koralewski Eliseo Hibert Davila Manuel Ivan Estrada Bernd Johannes Peter Wittels Wolfgang Jelkmann |
| Affiliation: | Freie Universit?t Berlin, Physiologisches Institut, Arnimallee 22, D-14 195 Berlin, Germany, DE Departamento de Fisiología y Biofìsica, Centro Estudios Actividad Física (CEAFI), Facultad de Medicina, Santiago, Chile, CL Research Study Group on Physical Performance, Army Hospital, Brünnerstra?e 238, A-1210 Vienna, Austria, AT Institut für Physiologie, Medizinische Universit?t Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany, DE |
| Abstract: | It was the aim of this study to investigate the time course of changes in the serum concentrations of vascular endothelial growth factor (VEGF) during a regular survival training programme combined with food and fluid deprivation and during a high altitude marathon run. We studied soldiers of the Austrian Special Forces performing survival training at sea-level and marathon runners of the Posta Atletica who crossed the border between Chile and Argentina at altitudes up to 4722?m. Baseline data collected before the 1-week of survival training showed that the soldiers had normal VEGF [n=8, 246.7?(SD 118.5)?pg?·?ml?1] serum concentrations which remained unchanged during the course of the study. Before the high altitude marathon the subjects showed normal VEGF serum concentrations [178?(SD 84.5)?pg?·?ml?1]. After the run VEGF concentrations were found to be significantly decreased [41.0?(SD 41.6)?pg?·?ml?1, P? |
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