| 绝经后子宫肌瘤中芳香化酶P450的表达及意义 |
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| 引用本文： | 夏晓梦,伍小敏,方小玲. 绝经后子宫肌瘤中芳香化酶P450的表达及意义[J]. 实用妇产科杂志, 2008, 24(12) |
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| 作者姓名： | 夏晓梦 伍小敏 方小玲 |
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| 作者单位： | 1. 中南大学湘雅二医院,湖南,长沙,410011
2. 广州市花都区人民医院,广东,广州,510800 |
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| 摘 要： | 目的:探讨芳香化酶P450(P450arom)在绝经后子宫肌瘤中的表达及其在子宫肌瘤发病中的作用。方法:选取100例子宫肌瘤患者,其中绝经后非萎缩性组40例,绝经后萎缩性组20例,绝经前增生期组20例,分泌期组20例。术前测定血清中雌二醇(E2)含量,术中取肌瘤及其相应肌层组织作免疫组织化学染色,检测P450arom的表达。结果:绝经后非萎缩性组与萎缩性组两组血清E2含量相比,差异无统计学意义(P>0.05)。P450arom在绝经后非萎缩性组、增生期及分泌期组肌瘤中的表达水平相比,差异无统计学意义(P>0.05),但均显著高于其相应肌层组织及绝经后萎缩性组(P<0.01);而P450arom在绝经后萎缩性组中的肌瘤表达水平与相应肌层组织相当,差异无统计学意义(P>0.05)。结论:P450arom在绝经后非萎缩性肌瘤中过度表达,可能导致雌激素原位合成增加,使其不萎缩或继续生长。
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| 关 键 词： | 芳香化酶P450 子宫肌瘤 绝经后 |
Expression of Aromatase Cytochrome P450 in Postmenopausal Uterine Leiomyoma |
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| XIA Xiaomeng,WU Xiaomin,FANG Xiaoling. Expression of Aromatase Cytochrome P450 in Postmenopausal Uterine Leiomyoma[J]. Journal of Practical Obstetrics and Gynecology, 2008, 24(12) |
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| Authors: | XIA Xiaomeng WU Xiaomin FANG Xiaoling |
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| Abstract: | Objective:To investigate the expression of aromatase cytochrome P450(P450arom) in postmenopausal uterine leiomyoma and the role of P450arom in the pathogenesis of uterine leiomyoma.Methods:100 cases of leiomyoma in different menstrual situation were examined P450arom by immunohistochemical technique,including 40 cases with symptomatic postmenopausal uterine leiomyoma,20 cases with regressive postmenopausal u-terine leiomyoma,20 cases of proliferative phase and 20 cases of secretory phase of premenopausal ut... |
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| Keywords: | Aromatase cytochrome P450 Uterine leiomyoma Post-menopause |
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