Different responses of mesenteric artery from normotensive and spontaneously hypertensive rats to nitric oxide and its redox congeners |
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Authors: | Orescanin Zorana S Milovanović Slobodan R Spasić Snezana D Jones David R Spasić Mihajlo B |
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Affiliation: | Department of Physiology, Institute for Biological Research Sinisa Stankovi?, Bulevar Despota Stefana 142, 11060 Belgrade, Serbia. |
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Abstract: | The conversion of nitric oxide (NO*) into its congeners nitrosonium (NO(+)) and nitroxyl (HNO/NO(-)) ions may have important consequences for signal transduction and physiological responses. Manganese-containing superoxide dismutase (MnSOD) may convert NO. into its redox congeners. In our current work, we have examined the mechanism of sodium nitroprusside (SNP)-induced relaxation of arteries, with or without endothelium, from both normotensive and spontaneously hypertensive (SH) rats in the absence and presence of MnSOD. SNP induced a greater degree of relaxation in normotensive than in SH rats. MnSOD antagonized SNP-induced relaxation and effect was greater in normotensive than hypertensive rats. However, MnSOD even potentiated SNP-induced relaxation in mesenteric arteries with endothelium from SH rats. Our results indicate that HNO/NO(-)-mediated relaxation is more effective in mesenteric artery smooth muscle from SH rats than from normotensive rats and that vascular dysfunction in SH rats is not solely endothelium-derived but involves changes in vascular smooth muscles. |
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