沙培林联合顺铂治疗恶性胸腔积液的观察与护理

目的:探讨沙培林联合顺铂治疗恶性胸腔积液的临床观察与护理方法,以达到减轻药物毒副反应和提高病人的生存质量的目的。方法:将96例恶性胸腔积液病人,随机分为两组。治疗组:在做好临床观察与护理的同时,胸腔注入沙培林和顺铂前,常规应用地塞米松、止痛剂、止呕剂,以预防药物的毒副反应;对照组:不作预防性用药,待到出现不良反应时做相应处理。分别观察两组毒副反应及体力状况。结果:治疗组发热、胸痛及恶心、呕吐症状发生率分别为12.5%(6/48),10.4%(5/48),10.4%(5/48),均明显低于对照组的31.3%(17/48),27.1%(13/48),25.0%(12/48),两组有显著的统计学差异(P<0.05)。卡氏体力评分≥60分治疗组则明显高于对照组(P<0.01)。结论:在沙培林联合顺铂治疗恶性胸腔积液中,经预防性用药,病人毒副反应轻,机体康复快,容易接受治疗,值得临床推广应用。

Observation and Nurse of OK-432 plus DDP in the treatment of malignant pleural effusion

Objective To investigate the clinical observation and nurse measures of picibanil(OK-432) plus cisplatin(DDP)in the treatment of malignant pleural effusion,in order to reduce the side-effects of the drug and improve survival quality of the patients.Method 96 patients of malignant pleural effusion were randomly divided into two groups.:One is therapy group: not only to carry on clinical observation and nurse but also to administrate desamethason,acetanilid and antiemetic to prevent the toxicities of the drug before the injection into thorax with OK-432 and DDP;Another is control group: not to administrate preventive drugs until the side-effects appearance,and then the side-effect and Karnofsky physical status between two groups were compared.Results The fever,chest pain and nausea-vomiting in therapy group were 12.5%(6/48),10.4%(5/480),10.4%(5/48),respectively versus 31.3%(17/48),27.1%(13/48),25.0%(12/48)in control group.There were statistically significant differences between two groups(P<0.05).Karnofsky physical status(KPS)≥60 in therapy group was higher than control group after treatment(P<0.01).Conclusion In the treatment of malignant pleural effusion with OK-432 plus DDP,the patients had a milder side-effects,get-well sooner and more acceptable to the treatment with preventive administration.It is worthy of extensive application in clinical status.