糖尿病性骨量减少及其影响因素探讨

检测了220例糖尿病患者的桡骨骨密度(BMD)、血钙(ca)、磷(P)、硷性磷酸酶(ALP)、空腹血糖(FBG)、C肽、甲状旁腺激素(PTH)、降钙索(CT)、24小时尿Ca和羟脯氨酸(HOP)。结果显示骨量减少有94例．为42．7％，其中BMD1SD44例，占20％，-2SD50例，占22．7%。BMD减少组24小时尿Ca、HOP、ALP明显高于骨量正常组(P＜0.01)；年龄、病程、血糖控制水平及伴糖尿病肾病是BMD变化的主要影响因素。在NIDDM组中，BMD与C肽／FBC的比值呈正相关(r=0．546，P＜0.01)。

A study on diabetes-induced osteopenia and its affecting factors

in this study, 220 diabetic patients received determination of bone mineral density (BMD)of radius, serum calcium (Ca), phosphorus (P), alkaline phosphatase (ALP), fasting blood glucose ( PBG),C-peptide, parathormone (PTH),calcitonin (CT), 24h urine calcium (24h U-Ca) and hydro xy proline (Hyp). The results indicated that 94 cases (42. 7%) developed osteopenia, of whom 44 cases (20%) had BMD lying within X-1 SD and 50 cases (22. 7%) had BMD slying within X-2 SD. The 24h U-Ca,Hyp and ALP in the groups with lower BMD were obviously higher than those in the groups with normal BMD ( P <0. 01 ). The age ,duration of diabetes,level of blood glucose and complication of diabetic nephropathy were main affecting factors in the changes of BMD. A positive correlation (r=0. 546,P <0. 01 ) between BMD and the ratio of C-peptide to FBG was observed in the non-insulin-dependent group.