靶部位及全身应用血管舒张药对皮瓣成活的实验研究

目的探讨局部和全身应用罂粟碱对新西兰兔腹壁下动脉皮瓣成活的影响。方法将24只体质量相近的雄性新西兰兔配成6个区组，每个区组的4只免分别随机分配到4个研究组中，每个研究组6只；建立新西兰兔左侧下腹壁浅动脉皮瓣模型，采用双盲法，按注射罂粟碱不同部位分为实验组A（皮瓣蒂部），实验组B（静脉注射），实验组C（皮瓣中央皮下组织），对照组（左侧臀部）；在术前、术后（注药前、注药后10min、60min），通过彩色多普勒观察皮瓣的血管分布、血流和手术后1周皮瓣的成活情况。结果皮瓣蒂部皮下注射较皮瓣中央皮下组织和臀部肌肉注射效果明强，差异有统计学意义（P〈0．05），皮瓣蒂部注射与静脉注射对皮瓣的血管显像差异无统计学意义（P〉0．05）。结论新西兰兔腹部移植皮瓣在皮瓣蒂部注射罂粟碱较臀部肌肉注射效果好，可改善皮瓣的血运，提高皮瓣的存活率。

Study of effective of skin flap with injecting vasodilatator in different location

Objective To stuay the influence of skin flap for inject vasodilatator through different pathway.Methods Twenty-four weight ClOSe to each other,male rabbit of New Zealand,random allocation to 4 groups.There are 6 rabbig in every group.To establish pattem of skin flap for left inferior beiiy arteria epigastria superficialis.4 groups accoring to inject location for papaverine divid to stalk of skin flap and intramuscular injection,intramuscular injection.Through color Doppler to observe blood vessel distribute,blood stream and skin flap.Results Compare with inject papaverine in stalk of skin flap more effectiveness than intramuscular injection(P＜0.05).Conclusion Injecting papaverine in stalk of skin flap more effectiveness than injecting papaverine in buttocks side.