药物对高原移居者睡眠呼吸紊乱警觉性作用初步研究

目的应用心理生理测验的途径检测探索高海拔地区抗低氧药物对移居者睡眠呼吸紊乱(SDB)警觉性的作用.方法选择驻守在海拔5380米高原12个月青年士兵24人,随机分为甲、乙两组,采用DDX-200型电脑多功能心理生理能力测试仪和ASC-545型血氧仪,监测前晚11.30时和早晨8.20时静息状态下的脑功能和血氧饱和度(SaO2),衡量其警觉性.甲组口服三普红景天胶囊,乙组口服乙酰唑胺片;均一次服药25天后,重复监测前晚和早晨静息状态下的脑功能及SaO2,并进行服药前后的对比评定.结果甲乙两组服药前晚、晨SaO2比较相近似,无显著性差异(p＞0.05)、服药后甲组晚、晨SaO2显著高于服药前(p＜0.05);服药后乙组晨SaO2显著高于服药前(p＜O.01).甲、乙组服药前晚、晨比较,视觉注意分配无显著性差异(p＞0.05);缺失记忆测验、甲组晚晨与乙组比较错误次数显著增多(p＜O.01),服药后亦相同.服药后甲组视觉注意分配测验晚操作总次数、正确次数,晨正确次数显著高于服药前(p＜0.01或p＜0.05),操作平均时间显著低于服药前(p＜O.01);缺失记忆测验晚错误次数显著多于服药后(p＜0.01);服药后乙组晚视觉注意分析总次数、正确次数显著多于服药前(p＜0.01或p＜0.05),服药前晚操作平均时间、晨错误次数、操作平均时间显著多于服药后(p＜0.01或p＜0.05);服药前缺失记忆测验晚晨错误次数显著我于服药后(p＜0.05).甲乙组视觉注意分配测验,甲组服药后晚测验总次数、正确次数显著多于乙组(p＜0.01),晨测验次数、正确次数、错误次数显著多于乙组(p＜0.01或p＜0.05).结论红景天与乙酰唑胺均能不同程度的改善和调节高原睡眠呼吸质量,减轻和改善SDB,提高大脑的警觉性水平.

Effects of Hongjingtian ( Chinese Herb) and Acetarolamide on the Vigilance of High Attitude Immigrants with Sleep Disordered Breathing

Objective:To Effects of Hongjingtian (Chinese Herb) and Acetarolamide on the vigilance of high attitude immigrants with sleep disordered breathing Methods: To determine the brain functions by vision-attention-distribute test of 24 young soldiers living on 5380 meters above sea level for 1 year and test their blood oxygen saturation (SaO 2) before going to sleep and the next morning The soldiers were randomly divided into two groups, group A received Hongjingtian capsules and group B acetarolamide The tests were repeated after 25 days medication Results: After taking the two medicines for 25 days, the SaO 2 increased obviously (p<0 05 and p<0 01 respectively) The average operate time decreased notably in both groups (p<0 01) In the memory-lose test, the times of wrong decreased after medication (p<0 05) But there was no difference of the above results between the two medicines Conclusion: Both Hongjingtian (Chinese Herb) and Acetarolamide can improve the vigilance of high attitude immigrants with sleep disordered breathing