| 内毒素休克后家兔血管反应性的变化规律及器官差异 |
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| 引用本文： | 陈玮,明佳,徐竞,杨光明,刘良明. 内毒素休克后家兔血管反应性的变化规律及器官差异[J]. 创伤外科杂志, 2008, 10(5) |
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| 作者姓名： | 陈玮 明佳 徐竞 杨光明 刘良明 |
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| 作者单位： | 第三军医大学大坪医院野战外科研究所第二研究室,创伤、烧伤与复合伤国家重点实验室,重庆,400042 |
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| 基金项目： | 国家重大基础研究项目(973)(2005CB522601) |
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| 摘 要： | 目的 了解内毒素休克后血管反应性的变化规律及器官差异.方法 家兔48只,随机分为6组,依次为正常对照组、给内毒素(LPS)后0.5、1、2、4、6小时组,分别测定各组肠系膜上动脉(SMA)、腹腔动脉(CA)和左肾动脉(LRA)离体血管环对去甲肾上腺素(NE)、乙酰胆碱(Ach)的收缩和舒张反应性.结果 内毒素休克后SMA对NE的收缩反应性早期轻度升高,晚期显著下降,对Ach的舒张反应性早期显著升高,晚期显著下降;CA对NE的收缩反应性早期显著升高,晚期显著下降,对Ach反应性呈持续高反应,峰值在早期;LRA认对NE的收缩反应性早期显著升高,晚期显著下降,对Ach的反应性早期显著升高,晚期无明显变化.结论 内毒素休克血管反应性呈现一定器官差异,这种差异可能与内毒素休克血流动力学改变及血液重分布有关.
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| 关 键 词： | 内毒素休克 血管反应性 器官差异 |
Changes and organ diversity of vascular reactivity following endotoxic shock in rabbits |
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| CHEN Wei,MING Jia,XU Jing,et al.. Changes and organ diversity of vascular reactivity following endotoxic shock in rabbits[J]. Journal of Traumatic Surgery, 2008, 10(5) |
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| Authors: | CHEN Wei MING Jia XU Jing et al. |
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| Affiliation: | CHEN Wei,MING Jia,XU Jing,et al.(State Key Laboratory of Trauma,Burns , Combined Injury,Department 2,Institute of Surgery Research,Daping Hospital,Third Military Medical University,Chongqing 400042,China) |
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| Abstract: | Objective To explore the changes and organ diversity of vascular reactivity following endotoxic shock.Methods Forty-eight rabbits were divided into 6 groups as follows: normal control group,and 0.5h,1h,2h,4h,6h group following LPS injection.The superior mesenteric artery(SMA),celiac artery(CA) and left renal artery(LRA) from each group were adopted to assay the vascular contraction and relaxation reactivity to NE and Ach.Results SMA reactivity to NE slightly increased in the early period,but decreased obvio... |
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| Keywords: | endotoxic shock vascular reactivity organ diversity |
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