| 进化生物技术--酶定向分子进化 |
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| 引用本文： | 张今,李爽,李宾,孙妍红. 进化生物技术--酶定向分子进化[J]. 医学分子生物学杂志, 2004, 1(6): 327-333 |
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| 作者姓名： | 张今 李爽 李宾 孙妍红 |
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| 作者单位： | 吉林大学分子酶学工程教育部重点实验室,长春市,130021;吉林大学分子酶学工程教育部重点实验室,长春市,130021;吉林大学分子酶学工程教育部重点实验室,长春市,130021;吉林大学分子酶学工程教育部重点实验室,长春市,130021 |
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| 摘 要： | 定向分子进化 (directedmolecularevolution)又称实验室进化 (laboratoryevolution)或进化生物技术(evolutionarybiotechnology)。它旨在体外模拟自然进化机制 (突变、重组和选择 ) ,使进化过程朝着人们需要的方向发展。定向分子进化的实质是达尔文进化论思想在分子水平上的延伸和应用。用进化和组合技术研究和解决复杂生物学和化学问题已成为化学和生物学迅猛发展的领域之一。
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| 关 键 词： | 酶 定向分子进化 体外 |
| 修稿时间： | 2004-10-26 |
Directed Molecular Evolution of Enzymes |
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| ZHANG Jin,LI Shuang,LI Bin,SUN Yanhong Key Laboratory for Molecular Enzymology and Engineering,the Ministry of Education,Jilin University,Changchun,,China. Directed Molecular Evolution of Enzymes[J]. Journal of Medical Molecular Biology, 2004, 1(6): 327-333 |
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| Authors: | ZHANG Jin LI Shuang LI Bin SUN Yanhong Key Laboratory for Molecular Enzymology Engineering the Ministry of Education Jilin University Changchun China |
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| Affiliation: | ZHANG Jin,LI Shuang,LI Bin,SUN Yanhong Key Laboratory for Molecular Enzymology and Engineering,the Ministry of Education,Jilin University,Changchun,130021,China |
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| Abstract: | Directed molecular evolution (laboratory evolution or evolutionary biotechnology) can simulate natural evolutionary mechanism (mutation, recombination and selection) in vitro and evolve enzyme as desired. The idea of directed molecular evolution is the extension and use of Darwinian Theory at molecular level. The application of evolutionary and combinatorial techniques to study and solve complicated biological and chemical problems has become one of the most dynamic fields in chemistry and biology. |
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| Keywords: | enzyme directed molecular evolution in vitro |
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