老年人非甾体类抗炎药致上消化道出血的临床特征分析

目的探讨老年人应用非甾体抗炎药(NSAIDs)致上消化道出血的临床特征。方法回顾性分析我院消化内科收治的NSAIDs相关性上消化道出血患者616例,按年龄分为老年组(≥60岁)416例和中青年组(<60岁)200例,分析两组临床特征的差异。结果老年组应用NSAIDs以阿司匹林为主,占55.8%(232/416),高于中青年患组(37.0%,74/200),两组比较差异有统计学意义(P<0.05);其血液常规及凝血常规指标与中青年组相比较差异无统计学意义(P>0.05);老年组服用NSAIDs药物后近期出血率(21.2%)低于中青年组(63.0%),两组比较差异有统计学意义(P<0.05)。老年组及中青年组上消化道出血患者的溃疡病史及Hp感染史比较差异无统计学意义(P>0.05)。结论老年NSAIDs相关上消化道出血的临床特征与青年患者不同,需予以个体化治疗。

Analysis of the clinical characteristics of upper gastrointestinal bleeding of elderly patients induced by non-steroidal anti-inflammatory drugs

Objective To investigate the clinical features of non-steroidal anti-inflammatory drugs （NSAIDs） caused upper gastrointestinal bleeding in elderly patients. Methods A retrospective analysis was performed in NSAIDs caused upper gastrointestinal bleeding, 616 cases admitted to gastroenterology department of our hospital were chosen. All the patients were divided into elderly group （≥65 years old, n =416） and young group （ 〈60 years old, n = 200 ）, the clinical characteristics were compared. Results The main NSAIDs use of elderly group was mainly aspirin （55.8% ,232/416）, there was significant difference between the two groups（ P 〈 0. 05 ）. There was no significant difference in the blood routine and coagulation between the two group （ P 〉 0. 05 ）. The recent bleeding rate of elderly group （ 21.2 % , 88/416 ） was lower than that of young group （ 63.0% , 126/200 ） , there was significant difference between the two groups（ P 〈 0. 05 ）. No significant difference was found in the history of ulcer and Hp infection between the two groups （ P 〉 0. 05 ）. Conclusion The clinical characteristics of upper gastrointestinal bleeding induced by NSAIDs in the elderly patients are different from those of patients with young or middie-age, and the elderly patients need individualized treatment.