59例抗真菌药物不良反应分析

目的了解我院抗真菌药物不良反应(ADR)发生的情况和特点,为临床安全、合理用药提供参考。方法收集我院2007-2012年抗真菌药物ADR报告59例,按患者年龄、性别、涉及药品种类、给药方式、ADR损害器官及主要临床表现等进行统计分析。结果 59例报告中,男33例,女26例。59岁以上发生率最高(23例,占38.98%)。涉及4类抗真菌药,以吡咯类为主(45例,占76.27%)。引起ADR的主要给药途径为静脉给药(43例,占72.29%)。ADR主要损害器官为皮肤及其附件损害(23.53%)和肝损害(23.53%)。结论合理应用抗真菌药,使用中应密切监测,避免严重ADR的发生。

Adverse drug reaction reports analysis of antifungals in 59 cases

Objective To understand the occurrence and characteristics of adverse drug reaction （ADR） of antifungals in our hospital, and provide reference for safe and rational drug use in clinic. Methods 59 ADR reports from 2007 to 2012 were collected and analyzed according to the patient＇s age and gender,drug types, medication methods, damage to organs, major clinical manifestations and so on. Results There were 33 males and 26 females in 59 ADR reports. The occurrence rate in the patients over 59 year-old was the highest（ n = 23,38.98% ）. Four kinds of antifungals were involved with azole in first place（ n = 45,76.27% ）. Intravenous administration was the main route（ n = 43, 72.29% ）. The main organs damaged by ADR were skin and its attachments（23.53% ）and liver damage（23.53% ）. Conclusion The use of antifungals should be reasonable under strict monitoring to avoid the occurrence of serious ADRs.