血必净注射液对自发性细菌性腹膜炎患者Th1/Th2亚群的影响

目的研究血必净注射液对乙型肝炎后肝硬化合并自发性细菌性腹膜炎患者机体Th1/Th2亚群的影响。方法将60例乙型肝炎后肝硬化合并自发性细菌性腹膜炎患者随机分成2组。对照组25例,使用抗生素和保肝等治疗;血必净组35例,在对照组治疗的基础上加用血必净注射液静脉滴注。采用流式细胞仪检测血必净注射液治疗肝硬化合并自发性细菌性腹膜炎患者前后血清的Th1、Th2细胞的变化。结果两组患者Th1、Th2均于治疗第4天达到峰值(P<0.05),然后下降;治疗第8天,两组患者Th1仍高于治疗前(P<0.05),Th2水平均降低(P<0.05)。治疗第4天、第8天,血必净组的Th1均高于对照组(P<0.05),两组Th2比较差异无统计学意义(P>0.05)。两组患者治疗后Th1/Th2平衡均向Th1漂移,血必净组更加显著(P<0.01)。结论血必净可以明显促进腹膜炎患者Th1应答,改善其促炎/抗炎反应平衡,促进炎症吸收,促进病情尽早康复。

Effect of xuebijing injection on Th1/Th2 subsets in patients with spontaneous bacterial peritonitis

Objective To study the effect of xuebijing injection on Thl/Th2 subsets in patients with type B hepatitis cirrhosis with spontaneous bacterial peritonitis. Methods 60 patients with type B hepatitis cirrhosis with spontaneous bacterial peritonitis were randomly divided into two groups. Control group （n = 25 ）was treated with common liver-protective medicine and antibiotics. Xuebijing group （ n = 35 ） was treated with normal treatment combined with xuebijing injection. The changes of Thl/Th2 subsets in patients with type B hepatitis cirrhosis with spontaneous bacterial peritonitis before and after xuebijing injection therapy were observed. Results The level of Thl, Th2 on both groups reached the peak at the 4th day after treatment（ P 〈 0. 05 ）, and then decreased. At the 8th day after treatment, the Thl of patients in both groups increased（ P 〈 0. 05 ）, and Th2 decreased（ P 〈 0. 05 ）. At the 4th and 8th day after treatment, the Thl subsets of xuebijing group were higher than that of control group （ P 〈 0.05 ）, and there was no significant difference in Th2 subsets between the two groups （P 〉 0.05）. The balance of Thl/Th2 is biased to Thl in both groups after treatment, and the changes in xuebijing group were more obvious than those of control group（ P 〈 0. 01 ）. Conclusion Xuebijing injection can promote the Thl-type response in patients with type B hepatitis cirrhosis with spontaneous bacterial peritonitis, repair the balance of anti-inflammatory/pro-inflammatory response, improve the absorbtion of inflammation and promote the rehabilitation of disease more quickly.