TP方案与FP方案用于晚期宫颈癌的临床疗效比较

目的探讨顺铂+氟尿嘧啶(FP方案)和顺铂+紫衫醇(TP方案)同步放射治疗在晚期宫颈癌的临床疗效和毒性反应。方法 57例晚期高危宫颈癌术后患者,随机分为FP组(FP方案同步放化组)28例;TP组(TP方案同步放化组)29例。FP组方案:顺铂40 mg/m2,第1³天静脉滴注,氟尿嘧啶1.0 mg/m2,第13天静脉滴注,氟尿嘧啶1.0 mg/m2,第1⁵天静脉滴注,共2个周期,每个周期为28 d。TP组方案:紫杉醇135 mg/m2,第1天静脉滴注;顺铂40 mg/m2,第15天静脉滴注,共2个周期,每个周期为28 d。TP组方案:紫杉醇135 mg/m2,第1天静脉滴注;顺铂40 mg/m2,第1⁴天静脉滴注,共2个周期,每个周期为28 d。对两组的临床疗效及不良反应进行对比分析。结果盆腔外转移率FP组低于TP组(P<0.05),盆腔内复发率两组相似(P>0.05),3年生存率两组分别为88.4%、70.9%(P<0.05)。两组不良反应相似,但骨髓抑制发生率TP组高于FP组(P<0.05)。结论 FP方案以及TP方案在晚期宫颈癌同步放射治疗的过程中,耐受性及疗效都得到保障,均显示出良好的治疗依从性,其中TP方案在近期的放射治疗效果较FP方案同步放射治疗组缓解率、有效率更高,是晚期宫颈癌较为理想的放射疗法之一。

Clinical efficacy of TP and FP program in the treatment of advanced cervical cancer

Objective To explore the clinical efficacy and toxic reactions of cisplatin and fluorouracil（ FP program） versus cisplatin and paclitaxel（ TP program） in neoadjuvant chemotherapy for cervical cancer. Methods 57 advanced cervical patients were randomly divided into two groups： FP group（ FP program,28 cases） and TP group（ TP program,29 cases）. FP group was given intravenous drip of cisplatin（ d1-3,with 40 mg /m2） and fluorouracil（ d1-5,with1.0mg /m2）,the treatment course lasted for 2 periods,28 d in each period. TP group was given intravenous drip of paclitaxel（ d1,with 135 mg/m2） and cisplatin（ d1-4,with 40 mg/m2）,the treatment course lasted for 2 periods too,28 d in each period. Clinical efficacy and adverse reactions of the two groups were compared. Results The rate of pelvic metastasis in group TP was lower than that in group FP（ P〈0. 05）,pelvic recurrence rate of the two groups were similar（ P 〉0. 05）,survival rate of the two groups in 3 years were 88. 4%,70. 9% respectively（ P〈0. 05）. There was no significant difference in adverse reactions between the two groups except myelosuppression,which of TP group was higher than FP group（ P〈0. 05）. Conclusion For patients with advanced cervical cancer,applying FP program and TP program in synchronous radiation has good tolerance and efficacy,with good treatment tolerance. The remission rate and efficacy of TP program is better than those of FP program,so TP program is an ideal treatment for advanced cervical cancer.