FT3对急性ST段抬高型心肌梗死病人危险分层作用

目的 探讨游离三碘甲状腺原氨酸（FT3）在急性ST段抬高型心肌梗死（STEMI）病人中的变化及与全球急性冠脉事件注册（GRACE）危险评分的关系。方法 连续入选STEMI病人73例。根据病人住院期间是否发生主要心血管不良事件（MACE）分为MACE组和无MACE组。于胸痛发作24 h内采集外周静脉血，测FT3。另随机选取本院同期健康体检者23例作为对照组。结果 各组FT3水平比较MACE组〈无MACE组〈对照组，差异有显著性（F=81.818，P〈0.01）。STEMI病人FT3水平与GRACE危险评分呈显著负相关（r=-0.580,P〈0.01）。结论 STEMI病人FT3水平降低，与病情严重程度相关；FT3可以作为STEMI病人危险分层的指标。

RISK STRATIFICATION OF FREE TRI-IODOTHYRONINE LEVER IN PATIENTS WITH ACUTE ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION

Objective To investigate the changes of free tri-iodothyronine （FT3） in acute ST-segment elevation myocardial infarction （STEMI） and its association with Global Registry of Acute Coronary Events （GRACE） risk score. Methods Seventy-three consecutive STEMI patients were enrolled, according to if the adverse major cardiac events （AMCE） happened during hospital stay, they were divided into AMCE group and no-AMCE group. The blood was collected within 24 hours after the onset of chest pain to determine FT3. Meanwhile,23 healthy individuals were enrolled to serve as controls. Results The levels of FT3 of subjects in the three groups were as follows：MACE group 〈no-MACE group〈 the control group （F=81.818,P〈0.01）. The level of FT3 in patients with STEMI was negatively correlated with GRACE risk score（r=-0.580,P〈0.01）. Conclusion The lower FT3 levers in STEMI patients are associated with the extent of severity of the disease, which can be used as an indicator for risk stratification.