| 前列腺素E_1的工艺优化 |
| |
| 引用本文： | 陈玉威,张月辉,董慧明. 前列腺素E_1的工艺优化[J]. 实用药物与临床, 2014, 0(6): 734-737 |
| |
| 作者姓名： | 陈玉威 张月辉 董慧明 |
| |
| 作者单位： | 辽宁省药物研究院,沈阳110015 |
| |
| 摘 要： | 目的对前列腺素E1提取工艺进行优化。方法以前列腺素E1含量为考察指标,对前列腺素E1提取工艺中孵育温度、提取时间、pH值、通氧纯度4个因素进行优化。结果最佳提取工艺条件为:孵育温度37℃、pH值8、提取时间1 h、通氧纯度为纯氧。结论在此条件下,前列腺素E1提取工艺稳定可行,能有效提高前列腺素E1的含量。
|
| 关 键 词： | 前列腺素E1 工艺 优化 正交试验 |
Process optimization of prostaglandin E1 |
| |
| CHEN Yu-wei,ZHANG Yue-hui,DONG Hui-ming. Process optimization of prostaglandin E1[J]. Practical Pharmacy and Clinical Remedies, 2014, 0(6): 734-737 |
| |
| Authors: | CHEN Yu-wei ZHANG Yue-hui DONG Hui-ming |
| |
| Affiliation: | ( Pharmaceutical Research Institute of Liaoning Province, Shenyang 110015, China) |
| |
| Abstract: | Objective To explore the best of prostaglandin E1extraction. Methods With prostaglandin E1content as index,the incubation temperature,pH,extraction time,purity of oxygen were optimized by orthogonal experiment.Results The optimal conditions were as follows： incubation temperature 37 ℃,pH value of 8,extraction time 1 h,pure oxygen purity. Conclusion Under the above conditions,the optimal extraction process of prostaglandin E1was feasible and stable,can effectively improve the content of prostaglandin E1. |
| |
| Keywords: | Prostaglandin E1 Process Optimization Orthogonal test |
| 本文献已被 维普 等数据库收录！ |
|
