熊去氧胆酸联合莫沙必利治疗胆汁反流性胃炎疗效分析

目的观察熊去氧胆酸联合莫沙必利治疗胆汁反流性胃炎(PBRG)的临床效果。方法选取60例原发性胆汁反流性胃炎患者,采用信封法随机分为2组,所有患者均常规戒烟酒,忌食脂肪丰富的食物。对照组在上述治疗的基础上口服莫沙必利,5 mg/次,3次/d。观察组在对照组的基础上加用熊去氧胆酸,100 mg/次,口服,3次/d。对比分析两组的临床疗效及不良反应。结果观察组腹胀、腹痛及口苦症状评分均明显低于治疗前及对照组治疗后(P<0.05);观察组恶心评分较治疗前明显降低(P<0.05),略低于对照组治疗后,但差异无统计学意义(P>0.05)。观察组、对照组的治疗总有效率分别为96.67%、20.00%,两组比较差异有统计学意义(P<0.05)。两组患者治疗期间均未见明显不良反应。结论熊去氧胆酸联合莫杀必利治疗PBRG,可起到协同作用,从而提高治疗效果,且无明显不良反应。

Efficacy analysis of bile reflux gastritis treated with ursodeoxycholic acid and mosapride

Objective To observe the effect of ursodeoxycholic acid and mosapride on bile reflux gastritis （ PBRG）. Methods 60 cases of patients with PBRG were randomly divided into two groups by envelope method. All the patients were given routine treatment including quiting alcohol and avoiding fat-rich foods;control group received mosapride orally,5 mg per time, three times daily; observation group was also given ursodeoxycholic acid orally, 100 mg per time,3 times daily. The clinical efficacy and adverse reactions of the two groups were compared. Results After treatment, the scores of bloating ,nausea, abdominal pain and mouth pain in observation group decreased significantly, and there were significant differences in the the scores of bloating, abdominal pain and mouth pain between the two groups（P 〈 0. 05 ）, the nausea scores in observation group was lower than that of control group without significant difference（ P 〉 0.05 ）. The total effective rate of observation group and control group were 96. 67% and 20. 00% , there were significant differences between the two groups （ P 〈 0. 05 ）. No obvious adverse reaction was found in the two groups during treatment. Conclusion Ursodeoxycholic acid and mosapride has synergistic effects in the treatment of PBRG,thereby enhance the therapeutic effect without significant adverse reaction.